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{ "type": "slideout", "content": { "title": "45-Metric List", "content": "\u003cp\u003e\u003cstrong\u003eCore totals (20)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eWeight\u003c\/li\u003e\u003cli\u003eBMI\u003c\/li\u003e\u003cli\u003eBody Fat Rate (aka body fat %)\u003c\/li\u003e\u003cli\u003eBody Fat Percentage\u003c\/li\u003e\u003cli\u003eFat Mass\u003c\/li\u003e\u003cli\u003eMuscle Mass\u003c\/li\u003e\u003cli\u003eSkeletal Muscle Mass\u003c\/li\u003e\u003cli\u003eMuscle vs Fat Ratio\u003c\/li\u003e\u003cli\u003eVisceral Fat\u003c\/li\u003e\u003cli\u003eMetabolic Age\u003c\/li\u003e\u003cli\u003eBasal Metabolic Rate (BMR)\u003c\/li\u003e\u003cli\u003eHydration (status\/level)\u003c\/li\u003e\u003cli\u003eWater Weight\u003c\/li\u003e\u003cli\u003eTotal Body Water (TBW)\u003c\/li\u003e\u003cli\u003eIntracellular Water (ICW)\u003c\/li\u003e\u003cli\u003eExtracellular Water (ECW)\u003c\/li\u003e\u003cli\u003eProtein Levels\u003c\/li\u003e\u003cli\u003eBone mineral content \/ “bone” metric (often marketed as bone density)\u003c\/li\u003e\u003cli\u003eHeart health \u003c\/li\u003e\u003cli\u003eFull-body segmental scan coverage (arms\/torso\/legs)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental fat % (5)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Fat %\u003c\/li\u003e\u003cli\u003eLeft Arm Fat %\u003c\/li\u003e\u003cli\u003eTrunk Fat %\u003c\/li\u003e\u003cli\u003eRight Leg Fat %\u003c\/li\u003e\u003cli\u003eLeft Leg Fat %\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/lean outputs (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eTrunk Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/water balance ratings (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eTorso Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Water Balance %\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental intracellular-water health (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eTorso ICW health (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg ICW health (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eScoring + insights shown in creative (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eOverall Health Score\u003c\/li\u003e\u003cli\u003eBody Composition Grade\u003c\/li\u003e\u003cli\u003eActivity Grade\u003c\/li\u003e\u003cli\u003eSleep Grade\u003c\/li\u003e\u003cli\u003eRight-vs-left limb difference flag (lean\/muscle asymmetry callout)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e" }, "width": 750, "transitionDuration": 150 }

{ "type": "slideout", "content": { "title": "11-modal", "content": "\u003ch4\u003eLean Mass Preservation During GLP‑1-Assisted Weight Loss in Engaged Digital Health Program Participants\u003c\/h4\u003e\n\u003cp\u003e\u003ci\u003eAn Outcomes Analysis of 6,990 Hume Health Premium Members\n \u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eHume Health Corp • Internal Outcomes Analysis • 2024\n Correspondence: research@humehealth.com • Methodology available on request\n\u003c\/p\u003e\n\u003ch4\u003eABSTRACT\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003eBackground.\u003c\/b\u003e GLP‑1 receptor agonists produce substantial weight loss but are associated with lean mass loss of\n 25–39%\n of total weight lost in published clinical trials. Lean mass is a primary determinant of resting metabolic rate, and\n its loss during weight reduction is associated with impaired weight maintenance following treatment cessation. This\n analysis examined lean mass outcomes in a real-world cohort of Hume Health premium platform members who met defined\n engagement criteria.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMethods.\u003c\/b\u003e Retrospective analysis of 6,990 Hume Health premium members on GLP‑1 therapy who completed a minimum\n of\n three body composition measurements per week via the Hume Body (8-sensor bioelectrical impedance analysis) and made\n weekly attestations of adherence to Pro.f AI protocol guidance. Body composition was measured at each weigh-in. The\n primary outcome was lean mass loss as a percentage of total weight lost, assessed from highest recorded weight (peak)\n to lowest recorded weight (nadir). Weighted mean lean mass loss was computed as the ratio of aggregate lean mass\n change to aggregate total weight lost across the full cohort.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eResults.\u003c\/b\u003e Mean baseline weight was 105.3 kg (SD 21.8). Mean total weight lost was 21.9 kg (SD 6.8),\n representing 21.3%\n of baseline body weight. The weighted mean lean mass loss as a percentage of total weight lost was 16.9%. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 12.7% of members preserved or increased lean\n mass over the measurement period. Among the 87.3% of members who lost lean mass, mean lean mass loss as a percentage\n of total weight lost was 22.0%.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\n Conclusions. \u003c\/b\u003e Hume Health premium members on GLP‑1 therapy demonstrated lean mass loss substantially below the\n 25–39%\n range documented in published clinical trials. These results are consistent with the hypothesis that\n high-frequency\n body composition monitoring combined with AI-guided protocol adherence supports favorable body composition\n outcomes\n during medically assisted weight loss.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKeywords:\u003c\/b\u003e \u003ci\u003eGLP‑1 receptor agonists; lean mass preservation; body composition; semaglutide; weight loss;\n bioelectrical impedance analysis; digital health\u003c\/i\u003e\u003c\/p\u003e\n \n\u003ch4\u003e1. INTRODUCTION\u003c\/h4\u003e\n\u003cp\u003eGlucagon-like peptide-1 (GLP‑1) receptor agonists represent a substantial advance in pharmacological obesity\n management. In the STEP 1 clinical trial, once-weekly subcutaneous semaglutide 2.4 mg produced mean total body weight\n loss of 14.9% over 68 weeks, compared to 2.4% in the placebo group receiving lifestyle intervention alone —\n approximately 6.2 times greater weight loss than lifestyle intervention alone.¹\u003c\/p\u003e\n\u003cp\u003eHowever, a consistent finding across GLP‑1 clinical trials is that a meaningful proportion of weight lost derives\n from lean tissue rather than adipose tissue. Neeland et al. documented lean mass reductions of 40–60% of total weight\n lost in some GLP‑1 trial cohorts, with substantial heterogeneity across studies.² Prado et al., in a commentary in The\n Lancet Diabetes \u0026 Endocrinology, reported lean mass loss of 25–39% of total weight lost across medically induced\n weight loss programs.³\u003c\/p\u003e\n\u003cp\u003eThis is clinically significant because skeletal muscle mass is a primary determinant of resting metabolic rate (RMR)\n — the baseline energy expenditure that determines whether a patient can sustain their new body weight after treatment\n ends.⁶ In the STEP 1 extension trial, participants who discontinued semaglutide without a structured metabolic exit\n protocol regained two-thirds of their prior weight loss within one year of stopping treatment.⁴\u003c\/p\u003e\n\u003cp\u003eThe Hume Health platform combines GLP‑1 therapy with high-frequency body composition measurement via bioelectrical\n impedance analysis (BIA), physician oversight informed by longitudinal tissue-level data, and an AI guidance system\n (Pro.f) that surfaces body composition patterns for clinical review and member adherence. This analysis examines\n whether this protocol-supported approach is associated with lean mass outcomes below published benchmarks.\n\u003c\/p\u003e\n \n\u003ch4\u003e2. METHODS\n\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e2.1 Study Design\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis was a retrospective cohort analysis of real-world member data from the Hume Health platform. The analysis period\n spanned active program enrollment through March 2026. The study was conducted under Hume Health Corp internal data\n governance protocols. Member data were de-identified prior to analysis. The study did not constitute human subjects\n research requiring institutional review board oversight under 45 CFR 46 as it involved retrospective analysis of\n de-identified operational data.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.2 Participants\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eEligible participants were Hume Health premium members who: (1) were actively enrolled in a GLP‑1 therapy program\n during the analysis period; (2) completed a minimum of three Hume Body body composition measurements per week\n throughout the measurement window; and (3) completed weekly attestations confirming engagement with and adherence to\n Pro.f AI protocol guidance. Members who did not meet all three criteria were excluded from analysis.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.3 Measurements\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBody weight and body composition were measured at each weigh-in using the Hume Pod, a bioelectrical impedance analysis\n device measuring whole-body and segmental lean mass, fat mass, and total body water. BIA measurements were recorded at\n consistent times relative to weigh-in. Lean mass at peak weight (highest recorded body weight during the measurement\n window) and lean mass at nadir weight (lowest recorded body weight) were identified for each member. Lean mass delta\n was computed as lean mass at nadir minus lean mass at peak. Weight loss was computed as peak weight minus nadir\n weight.\n\u003c\/p\u003e\n\u003cp\u003eLean mass loss as a percentage of total weight lost was computed for each member as: (|lean mass delta| \/ weight\n loss) × 100, where lean mass delta was negative for members who lost lean mass and positive for members who preserved\n or gained lean mass. The primary aggregate outcome — weighted mean lean mass loss as a percentage of total weight lost\n — was computed as: (sum of lean mass deltas across all members \/ sum of total weight lost across all members) × 100,\n reflecting the population-level ratio of lean mass change to total weight change.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.4 Statistical Analysis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDescriptive statistics were computed for all primary and secondary outcomes. Continuous variables are reported as\n mean (standard deviation) and median. The weighted mean was used as the primary outcome measure for lean mass loss as\n a percentage of total weight lost, as it accounts for variation in total weight lost across members and reflects the\n aggregate population-level body composition response. Members who preserved or gained lean mass during the measurement\n period (lean mass delta ≥ 0) are included in all analyses; their inclusion in the weighted mean computation reduces\n the aggregate lean mass loss percentage relative to analyses restricted to members with lean mass loss.\u003c\/p\u003e\n\u003ch4\u003e3. RESULTS\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e3.1 Participant Characteristics\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA total of 6,990 members met all eligibility criteria and were included in the analysis. Baseline characteristics are\n presented in Table 1.\u003c\/p\u003e\n \n\u003cdiv class=\"table_drawer\"\u003e\n \u003cp\u003eTable 1. Baseline Participant Characteristics (n = 6,990)\u003c\/p\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eCharacteristic\u003c\/th\u003e\n \u003cth\u003eValue\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eSample size (n)\u003c\/td\u003e\n \u003ctd\u003e6,990\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean baseline weight, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e105.3 (21.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian baseline weight, kg\u003c\/td\u003e\n \u003ctd\u003e102.3\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMeasurement frequency (minimum)\u003c\/td\u003e\n \u003ctd\u003e3 weigh-ins per week\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eProof engagement attestation\u003c\/td\u003e\n \u003ctd\u003eWeekly (required for inclusion)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.2 Weight Loss Outcomes\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eMean total weight lost was 21.9 kg (SD 6.8), representing a mean reduction of 21.3% (SD 6.7%) of baseline body\n weight. Median weight lost was 19.6 kg, representing 20.0% of baseline body weight. Weight loss outcomes are presented\n in Table 2.\u003c\/p\u003e\n \n\u003cp\u003eTable 2. Weight Loss Outcomes\u003c\/p\u003e\n\u003cdiv class=\"table_drawer2\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e21.9 (6.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e19.6\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, % of baseline (SD)\u003c\/td\u003e\n \u003ctd\u003e21.3% (6.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, % of baseline\u003c\/td\u003e\n \u003ctd\u003e20.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMinimum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e15.7\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMaximum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e75.4\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cb\u003e3.3 Lean Mass Outcomes\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean lean mass loss as a percentage of total weight lost was 16.9% across all 6,990 members. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 890 members (12.7%) preserved or increased\n lean mass over the measurement period (lean mass delta ≥ 0). Among the 6,100 members (87.3%) who lost lean mass, the\n mean lean mass loss as a percentage of total weight lost was 22.0%. Lean mass outcomes are presented in Table 3.\u003c\/p\u003e\n \n\u003cp\u003eTable 3. Lean Mass Outcomes\u003c\/p\u003e\n\u003cdiv class=\"table_drawer3\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eWeighted mean lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e16.9%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e19.4%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers preserving or gaining lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e890 (12.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers losing lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e6,100 (87.3%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean lean mass loss, % of total weight lost (among those with lean mass loss)\u003c\/td\u003e\n \u003ctd\u003e22.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003ePublished benchmark (Prado et al., 2024; Neeland et al., 2024)\u003c\/td\u003e\n \u003ctd\u003e25–39% (range across GLP-1 trials)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.4 Interpretation of the Weighted Mean Outcome\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean of 16.9% reflects the aggregate population-level ratio of total lean mass change to total weight\n lost across all members. Because members who preserved or gained lean mass (12.7% of the cohort) contribute negative\n lean mass loss values to the numerator, the weighted mean is lower than the mean computed among members who lost lean\n mass exclusively (22.0%). Both measures are reported to provide transparency regarding cohort composition. The\n weighted mean is the primary outcome because it most accurately represents the population-level body composition\n impact of the program.\u003c\/p\u003e\n\u003ch4\u003e4. DISCUSSION\n\u003c\/h4\u003e\n\u003cp\u003eThis analysis demonstrates that Hume Health premium members on GLP‑1 therapy, who met defined body composition\n monitoring and AI protocol engagement criteria, experienced lean mass loss substantially below the benchmarks\n documented in published GLP‑1 clinical trials. The weighted mean lean mass loss of 16.9% of total weight lost compares\n favorably to the 25–39% range reported by Prado et al.³ and the 40–60% upper range reported in some cohorts by Neeland\n et al.²\n\u003c\/p\u003e\n\u003cp\u003eThe mechanism by which frequent body composition measurement and protocol-guided engagement may attenuate lean mass\n loss is consistent with established physiology. Skeletal muscle mass is the primary determinant of resting metabolic\n rate.⁶ Interventions that preserve lean mass during caloric restriction — including higher protein intake, resistance\n exercise, and dose calibration timed to body composition response — are documented to reduce lean mass loss during\n weight reduction. The Hume platform protocol facilitates tissue-level visibility that enables these calibrations in\n near real-time; the present analysis cannot isolate which components of the program contributed to the observed\n outcomes.\n\u003c\/p\u003e\n\u003cp\u003eThe finding that 12.7% of members preserved or gained lean mass during GLP‑1-assisted weight loss is notable. This\n subgroup is likely influenced by favorable baseline characteristics, behavioral factors, and variability in BIA\n measurement across conditions, and should not be interpreted as a program-level guarantee of lean mass preservation.\n Its inclusion in the weighted mean reduces the reported aggregate lean mass loss figure relative to analyses\n restricted to members who lost lean mass.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.1 Limitations\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis has several limitations that should be considered when interpreting results. First, the study is\n retrospective and observational, without a concurrent control group. Comparison to published clinical trial benchmarks\n involves differences in population, measurement methodology, and GLP‑1 agent. Second, body composition was measured\n via bioelectrical impedance analysis rather than dual-energy X-ray absorptiometry (DXA) or magnetic resonance imaging\n (MRI), which are considered the reference standards for lean mass quantification. BIA measurements are sensitive to\n hydration status, time of measurement, and device calibration, and may produce systematic differences relative to\n DXA-derived lean mass values. Third, the cohort consists of premium-tier members who met a minimum engagement\n threshold; results may not generalize to members with lower engagement frequency or to non-engaged GLP‑1 users.\n Fourth, no information on dietary protein intake, resistance exercise participation, or specific GLP‑1 agent and\n dosing schedule was incorporated into this analysis, and these variables are likely to influence lean mass outcomes.\n Fifth, the duration of the measurement window varied across members and was determined by the interval between peak\n and nadir weight rather than a fixed protocol period.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.2 Future Directions\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eProspective controlled study designs with standardized measurement protocols, dietary and exercise co-variate\n capture, and DXA-validated BIA calibration would provide stronger evidence for the role of high-frequency monitoring\n and AI-guided adherence in lean mass preservation during GLP‑1 therapy. Subgroup analyses examining the impact of\n engagement frequency, protein intake, resistance training participation, and GLP‑1 agent on lean mass outcomes would\n further characterize the mechanisms underlying these findings.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5. CONCLUSIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAmong 6,990 Hume Health premium members on GLP‑1 therapy who met defined body composition monitoring and AI protocol\n engagement criteria, the weighted mean lean mass loss as a percentage of total weight lost was 16.9%. This is\n substantially below the 25–39% range reported in published GLP‑1 clinical trial literature. The median lean mass loss\n was 19.4%. These findings are consistent with the hypothesis that high-frequency tissue-level monitoring, combined\n with AI-guided protocol adherence and physician oversight informed by body composition data, supports favorable lean\n mass outcomes during medically assisted weight loss. Prospective controlled research is needed to confirm these\n findings and to isolate the active components of the platform protocol.\n\u003c\/p\u003e\n \n\u003ch4\u003eREFERENCES\u003c\/h4\u003e\n \n\u003cp\u003e1. Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl\n J Med. 2021;384(11):989–1002. doi:10.1056\/NEJMoa2032183.\u003c\/p\u003e\n\u003cp\u003e2. Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and\n mitigation strategies. Diabetes Obes Metab. 2024;26(Suppl 4):16–27. doi:10.1111\/dom.15728.\u003c\/p\u003e\n\u003cp\u003e3. Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB. Muscle matters: the effects of medically induced weight loss on\n skeletal muscle. Lancet Diabetes Endocrinol. 2024;12(11):785–787. doi:10.1016\/S2213-8587(24)00272-9.\u003c\/p\u003e\n\u003cp\u003e4. Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of\n semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–1564. doi:10.1111\/dom.14725.\u003c\/p\u003e\n\u003cp\u003e5. Hume Health Corp. Lean Mass Preservation in GLP‑1 Members: An Internal Outcomes Analysis. 2024. Analysis of 6,990\n premium members. Methodology available on request: research@humehealth.com.\n\u003c\/p\u003e\n\u003cp\u003e6. Ravussin E, Bogardus C. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Appl\n Physiol. 1989;66(3). PMID:2243122.\n\u003c\/p\u003e\n \n\u003cp\u003e\u003cb\u003eDisclosure Statement\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis was conducted by Hume Health Corp using data from the Hume Health platform. Hume Health Corp is the\n developer of the body composition monitoring hardware (Hume Body Pod) and AI guidance system (Pro.f) evaluated in this\n analysis. No external funding was received. The analysis has not undergone independent peer review. Investigators have\n an inherent commercial interest in the outcomes described.\u003c\/p\u003e" }, "width": 750, "transitionDuration": 150 }

HSA/FSA eligible

(4.7/5.0) 2,955 Reviews

The Hume Band

€245,36

€327,14

or

Make 18 payments of €13,63.

The Hume Band

€245,36

€327,14

or

Make 18 payments of €13,63.

299 entries to win a G-Wagon

Most people don’t realize their health is trending downward until burnout, illness, or rapid aging hit. The Hume Band gives early warnings by tracking how your daily habits affect your future—so you know if you’re investing in your health or quietly draining it.

HSA/FSA eligible

45-Day Return Policy

Free Worldwide Shipping

Choose Warranty Protection:

1 Year Included

10 Years €45,95

ADD TO CART

Hume Band Lifetime Warranty

Protect your Hume Band for life. If anything ever goes wrong, send it back and we'll replace it with a brand-new one — no deductibles, no hassle.

✔︎ Selected by 82% of our customers

Only €45,95 EUR

or 18 payments of €13,63 with

1-Year Warranty

Free Shipping

Free Return

Next Batch Ships:

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April 22nd

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See it in action

The Award-Winning Longevity Band

Extending your lifespan is no longer a far-fetched dream. Add healthy decades to your life with advanced diagnostics, personalized health plans, and smarter daily decisions.

Live Longer and Live Better.
Combat the decline in energy that comes with aging
Build resilience to slow the aging process
Understand how your daily habits affect your longevity
Make informed, proactive health decisions based on data

Comparison

Hume Band

Others

Focus

Longevity, disease detection,
healthspan

Strain, recovery, athletic
performance, lifespan limited to
premium*

Data Ownership

You own your health
data (exportable)

You don’t own your
data (locked behind membership)

Subscription
Required?

No, One time purchase
with option to upgrade to premium

Yes - $30/month (or more)

Body Composition
Tracking

Yes, via Hume Pod

No

Digital Twin / AI
insights

Yes, future-ready
predictive insights

No (basic insights only)

Holistic Health
Coaching

Yes, Science-backed, longevity-
focused

Limited to performance/recovery tips

Longevity Metrics
(HRV, Resilience)

Yes, with longevity index,
metabolic momentum
and capacity

HRV only

Price

One-time purchase: $199-$249 (no
subscription)

$300-480/year (ongoing)

About the App

The Hume Health App is free for all Hume Band members, giving you access to core metrics like your Metabolic Capacity, Metabolic Momentum, Health Score, and more.

You can also upgrade to Premium Membership to unlock personalized, AI-powered coaching and feedback—designed to help you improve, faster.

Technical specifications

Wear It Anywhere

Comfortable enough to wear non-stop thanks to new, durable SuperKnit bands, but flexibly designed to be worn off your wrist 24/7

Waterproof

The Hume Band sensor is IP68 dustproof and water-resistant at depths up to 1 meter (roughly 3.2 feet) for up to 2 hours - so you can continue to capture your data with zero interruptions

Sensors

5 LEDs and 4 photodiodes capture your data more often than most wearables, providing best-in-class accuracy validated in lab studies and with third-party testing.

Battery Life

Up to 14 days of battery on a single charge* Typically charges in 20-80 minutes, depending on battery level

Connectivity

Bluetooth® Low Energy Automatic firmware updates via Hume Health App EMF-safe Allows airplane mode FCC-certified

App

Free app included to track all metrics. Premium upgrade add-on available for AI-driven coaching

FAQ

What makes the Hume Band different from other wearables?

The Hume Band isn’t just about fitness—it’s about future-proofing your health. We track longevity markers, showing how your habits are either speeding up or slowing down aging. Our unique metrics, like Metabolic Momentum and Metabolic Capacity, help you live longer, prevent chronic illness, and optimize your body for a healthier future. This isn’t just data—it’s a roadmap to a longer, stronger life.

What raw data does the Hume Band track and measure?

Continuous heart rate monitoring
Heart Rate Variability (HRV)
Blood oxygen levels (SpO2)
Sleep stages (light, deep, REM, awake)
Sleep quality and efficiency
Activity levels and movement patterns
Strain and recovery
Skin temperature
Blood Pressure (To be released in future app update, pending FDA approval)

What is “longevity,” and how does the Hume Band support it?

Longevity means living a longer, healthier life—free from preventable diseases. The Hume Band helps by continuously tracking and interpreting signals from your body to:

Spot early signs of imbalance or chronic risk
Monitor how daily habits impact your aging process
Provide insights to improve healthspan—not just lifespan

On average, Hume Band users gained an extra 39 days of life in their first year with Hume

Our tools are designed to help you make small changes that compound into big results over time.

Do I need a subscription to use the Band?

No subscription is required to use the Band or access your raw data.

However, if you'd like AI-driven insights, personalized longevity coaching, and deep health analysis, you can subscribe to Hume Premium starting at $8.99/month. This supports the computing power needed to deliver real-time, intelligent health feedback.

Is the Band waterproof or sweatproof?

Yes. The Hume Band is IP68-rated—meaning it's:

Dustproof
Water-resistant up to 1 meter (3.2 feet) for up to 2 hours

Perfect for showers, swimming, and workouts—no interruptions.

What is the battery life of the Hume Band?

Up to 14 days of battery life with typical use
Fast charging: Full charge in approximately 30 minutes

Note: Frequent syncing and continuous tracking may slightly reduce battery life.

What wrist sizes does the Band fit?

The Hume Band features an adjustable strap that fits a wide range of wrist sizes comfortably.

Is the Band compatible with my phone?

Yes. The Hume Band works with:

iOS Devices

iPhone 8 and newer
iOS 14.0 and above

Android Devices

Android 8.0 (Oreo) and above

Can I buy the Band without the Hume Pod?

Yes. The Hume Band works perfectly on its own for daily tracking.

The Hume Pod is an optional companion device that scans your body composition (body fat, muscle mass, etc.) for a more complete health picture—but it's not required.

Shipping & Returns

Free Shipping
Shipping is free for all global orders over $20.

Shipping Time
Most orders are shipped within 1 business day and delivered within 3-5 business days.*

Global Shipping
We also ship to all international countries.

Returns
100% Satisfaction Guaranteed. We welcome returns within 45 days of receipt for a full refund, even used and opened products. If I dont' like it? Can I return it? Absolutely! We know you're going to love our products, but we understand you can't be sure now. That is why we offer a 45-day free trial. For more information, take a look at our Refund & Returns page.

Trusted Delivery
USPS, DHL, FedEx

John Cardiff, PHD

Author of the Longevity Blueprint, Researcher, Board Member

It’s finally about time we start measuring our metabolic momentum which is the key driver when it comes to longevity. The Hume Band is going to be a game changer for many

Free Shipping + Free App

2,955 Reviews

Hume Band

18 interest-free payments of €13,63

~~€327,14~~ €245,36

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Backed by science, trusted by the best

I can’t say enough good things about the Hume Band. One of the most impressive features for me has been the Metabolic Capacity. It flagged signs of strain on my body before I even realized something was wrong—turns out I had a chest infection! Thanks to the early warning, I was able to get checked out and start treatment before things got worse.

Addison N.

As a doctor, I’m impressed Most of my patients come in wanting a "magic pill" for longevity, but the truth is, daily habits matter more tha

Jack W

I am extremely pleased I am extremely pleased with how Hume handled an issue I was having with my Band. My battery kept draining faster and faster and I decided to reach out to customer service to see what could be done.

Liam T.

Great experience across the board. The team at Hume was easy to reach, helpful, efficient and understanding. Very impressed with the customer service I received.

Grace N.

I can’t say enough good things about the Hume Band. One of the most impressive features for me has been the Metabolic Capacity. It flagged signs of strain on my body before I even realized something was wrong—turns out I had a chest infection! Thanks to the early warning, I was able to get checked out and start treatment before things got worse.

Addison N.

As a doctor, I’m impressed Most of my patients come in wanting a "magic pill" for longevity, but the truth is, daily habits matter more tha

Jack W

I am extremely pleased I am extremely pleased with how Hume handled an issue I was having with my Band. My battery kept draining faster and faster and I decided to reach out to customer service to see what could be done.

Liam T.

Great experience across the board. The team at Hume was easy to reach, helpful, efficient and understanding. Very impressed with the customer service I received.

Grace N.

Backed by science, trusted by the best

30 day risk-free guarantee Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Free US shipping Lorem ipsum dolor sit amet, consectetur adipiscing elit.
Flexible subscription Lorem ipsum dolor sit amet, consectetur adipiscing elit.

Backed by science, trusted by the best

Optimize Biological Age and Live Better

Hume Band tracks your biological age and metabolic
momentum, showing if your habits are slowing down or
speeding up aging. Feel younger, live longer — with data to
back it up.

Reverse Age-Related Energy Decline

Track your metabolic capacity — your body’s internal battery
— and know when to push or recover. Reclaim energy, boost
resilience, and stop burning out.

Detect Chronic Illness Before It’s Too Late

Hume spots early signs of inflammation and illness through
HRV, sleep, and temperature. Get weekly health scores and
personalized reports so you can act early — not after it’s too
late.

Optimize Biological Age and Live Better

Hume Band tracks your biological age and metabolic
momentum, showing if your habits are slowing down or
speeding up aging. Feel younger, live longer — with data to
back it up.

Reverse Age-Related Energy Decline

Track your metabolic capacity — your body’s internal battery
— and know when to push or recover. Reclaim energy, boost
resilience, and stop burning out.

Detect Chronic Illness Before It’s Too Late

Hume spots early signs of inflammation and illness through
HRV, sleep, and temperature. Get weekly health scores and
personalized reports so you can act early — not after it’s too
late.

Members gained an average of +6.8 Years of extra lifespan from healthier habits

Hume Band 2.0 es mucho más que una pulsera...

Te muestra todo lo que ocurre en tu cuerpo. Estés entrenando, o no.

Comparativa

Hume Band

Others

Enfoque

Longevidad, detección de enfermedades y años de vida saludable

Esfuerzo, recuperación, rendimiento deportivo y longevidad limitada a la suscripción premium*

Propiedad de los datos

Tú eres el propietario de tus datos de salud (puedes exportarlos)

No eres el propietario de tus datos (están vinculados a la suscripción)

¿Requiere
suscripción?

No. Compra única, con opción de pasar a Premium

Sí - 30 $/mes o más

Seguimiento de la
composición corporal

Sí, mediante Hume Pod

No

Gemelo digital / información
de IA

Sí. Información predictiva preparada para el futuro

No (solo información básica)

Coaching completo
de salud

Sí. Basado en la ciencia y centrado en la longevidad

Limitado a consejos sobre rendimiento y recuperación

Métricas de longevidad

Sí, con índice de longevidad, impulso metabólico y capacidad

Solo HRV

Precio

Compra única: 199–249 $ (sin suscripción)

300–480 $/año (coste recurrente)

Tu edad real

Un coaching que más más allá del esfuerzo

Otros dispositivos se centran en tus entrenamientos y tu recuperación.

Hume es un sistema integral de longevidad, con herramientas para detectar posibles problemas de salud, comprender el envejecimiento y optimizar tu salud.

La edad biológica es una cifra.

La capacidad metabólica es un sistema.

Así te lo explica Hume:

Así te lo explica Hume:
“Tu impulso es 82. La semana pasada ganaste 3,2 días de vida. Esto es lo que puedes hacer para ganar aún más”

Así te lo explican otros dispositivos:

Así te lo explican otros dispositivos:
“Tu edad biológica es 37.”

No nos limitamos a decirte qué edad tienes. Te ayudamos a rejuvenecer y a demostrarlo.

Acceso ilimitado

Sin cuotas mensuales para acceder a tu propia salud

Hume:

Hume: compra única. Premium opcional*

Otros:

Otros: 30 $/mes solo para acceder a tus datos.

Creemos que tus datos de salud no deberían estar condicionados a una suscripción.
Con Hume Band 2.0, el dispositivo es tuyo. Y también lo son tus datos y la información que obtienes de ellos. Para siempre.

Longevidad

Métricas reales de longevidad, no solo HRV

Hume:

Hume: Impulso metabólico, capacidad, resiliencia y un índice completo de longevidad.

Otros:

Otros: Solo esperanza de vida. La HRV es una pieza más del puzzle.

Hume te ofrece una visión completa y te muestra cómo está cambiando realmente tu cuerpo con el paso del tiempo.

Conoce tu cuerpo

Medición directa: no solo inferencias

Otros dispositivos calculan el envejecimiento a partir de datos como la HRV, el sueño y la frecuencia cardíaca.

Hume lo mide directamente.

Hume Band 2.0 y Hume Pod analizan tus biomarcadores reales de grasa, músculos y tejidos, donde realmente se producen los cambios asociados al envejecimiento.

Las estimaciones pueden ser valiosas...

Pero los datos directos son mucho más exactos.

Wake Up Stronger,<br>Healthier & More<br> Resilient

Metabolic Momentum

Wake Up Stronger,
Healthier & More
Resilient

Your body heals and regenerates while you rest. Hume Band tracks your metabolic capacity. A higher Metabolic Capacity means better endurance, faster recovery, and greater resilience with age—like sharpening a sword that lasts longer, not dulling with time.

Understand if you’re building momentum

Your metabolic momentum shows how strong your body is when it comes to fighting aging.  Like a snowball rolling downhill, good health habits build momentum that helps you age slower and feel more alive.

Track your pace of aging

Directky track how your lifestyle speeds up or slows down aging, so you can boost vitality and take coontrol.

Actionalble Coaching to improve your body's Momentum

Get weekly indights and coaching on the right ways or things you need to do to slow aging but also to add extra days your life

Understand if you’re building momentum

Your metabolic momentum shows how strong your body is when it comes to fighting aging.  Like a snowball rolling downhill, good health habits build momentum that helps you age slower and feel more alive.

Actionalble Coaching to improve your body's Momentum

Get weekly indights and coaching on the right ways or things you need to do to slow aging but also to add extra days your life

Stay Active, Energized <br> & Aging-Resistant

Metabolic Capacity

Stay Active, Energized
& Aging-Resistant

Hume Band helps you balance strain and recovery, so you can maintain strength, mobility, and energy for years to come.

Catch Health Risks <br>Before They Slow You <br>Down

Chronic Illness Detection

Catch Health Risks
Before They Slow You
Down

Your body heals and regenerates while you rest. Hume Band tracks your metabolic capacity. A higher Metabolic Capacity means better endurance, faster recovery, and greater resilience with age—like sharpening a sword that lasts longer, not dulling with time.

Hume Pod Helps You
Make the Right Ones.

Powered by AI and Machine Learning, Hume+ is an enhanced in-app health experience to help anyone create routines that provide a positive feedback loop.

Up to 9.4
years of
extra life

Up to 23% slower
physiological
aging

Up to 41%
increase in
energy levels

Up to 2x feeling
motivated and
empowered daily

2024 & 2025 Women’s Health Health Awards

2025 Elle Health Awards

2024 & 2025 Most Innovative Companies

2025 Best Wellness Items

Thousand of reviews from extraordinary people like you

See more reviews

(4.8/5.0) 89,503 Reviews

As a doctor, I’m impressed Most of my patients come in wanting a "magic pill" for longevity, but the truth is, daily habits matter more than anything. That’s why I was thrilled to discover the Hume Band. Unlike other wearables that focus on generic metrics, it tracks metabolic capacity—a key indicator of cellular health and aging. The data is presented in a way that’s accessible (no medical degree required!), and I’ve started recommending it to patients who want to take control of their health. One diabetic patient even reduced his insulin resistance by 20% after using the band’s insights to tweak his exercise and meal timing. For anyone serious about preventive health, this is a game-changer.

I can’t say enough good things about the Hume Band. One of the most impressive features for me has been the Metabolic Capacity. It flagged signs of strain on my body before I even realized something was wrong—turns out I had a chest infection! Thanks to the early warning, I was able to get checked out and start treatment before things got worse. The Band itself is super comfortable to wear all day and night. It gives me detailed insights on how my habit is impacting my energy levels and how to increase my metabolic capacity, and now I truly listen to what my body needs. The app is really intuitive, and the health data feels incredibly personalized and accurate. If you’re looking for a smart health tracker that goes beyond tracking fitness and sleep, the Hume Band is the one. I genuinely feel more in tune with my health, and in this case, it may have even helped me catch a serious issue early. Highly recommended!

I bought this on a whim—now I can’t imagine life without it.
I wasn’t sure what to expect, but the Hume Band has become my daily health coach. It tracks things I didn’t even know mattered (like metabolic momentum) and shows me exactly how my choices affect my body. The app is sleek and user-friendly, and I love the weekly reports. My partner saw my results and ordered one for himself—now we’re both hooked!

I’ve tried every health tracker out there, and the Hume Band is in a league of its own. Most wearables just count steps or monitor heart rate, but the Hume Band goes deeper—tracking metabolic momentum and capacity to show how my daily habits impact my long-term health. The app breaks everything down in a way that’s easy to understand, and I’ve already made small tweaks (like adjusting my meal timing and sleep routine) that have had a huge impact on my energy. If you’re serious about longevity, this is a must.

As a doctor, I’m impressed Most of my patients come in wanting a "magic pill" for longevity, but the truth is, daily habits matter more than anything. That’s why I was thrilled to discover the Hume Band. Unlike other wearables that focus on generic metrics, it tracks metabolic capacity—a key indicator of cellular health and aging. The data is presented in a way that’s accessible (no medical degree required!), and I’ve started recommending it to patients who want to take control of their health. One diabetic patient even reduced his insulin resistance by 20% after using the band’s insights to tweak his exercise and meal timing. For anyone serious about preventive health, this is a game-changer.

I can’t say enough good things about the Hume Band. One of the most impressive features for me has been the Metabolic Capacity. It flagged signs of strain on my body before I even realized something was wrong—turns out I had a chest infection! Thanks to the early warning, I was able to get checked out and start treatment before things got worse. The Band itself is super comfortable to wear all day and night. It gives me detailed insights on how my habit is impacting my energy levels and how to increase my metabolic capacity, and now I truly listen to what my body needs. The app is really intuitive, and the health data feels incredibly personalized and accurate. If you’re looking for a smart health tracker that goes beyond tracking fitness and sleep, the Hume Band is the one. I genuinely feel more in tune with my health, and in this case, it may have even helped me catch a serious issue early. Highly recommended!

I bought this on a whim—now I can’t imagine life without it.
I wasn’t sure what to expect, but the Hume Band has become my daily health coach. It tracks things I didn’t even know mattered (like metabolic momentum) and shows me exactly how my choices affect my body. The app is sleek and user-friendly, and I love the weekly reports. My partner saw my results and ordered one for himself—now we’re both hooked!

I’ve tried every health tracker out there, and the Hume Band is in a league of its own. Most wearables just count steps or monitor heart rate, but the Hume Band goes deeper—tracking metabolic momentum and capacity to show how my daily habits impact my long-term health. The app breaks everything down in a way that’s easy to understand, and I’ve already made small tweaks (like adjusting my meal timing and sleep routine) that have had a huge impact on my energy. If you’re serious about longevity, this is a must.

Understand if you’re building momentum

Track your pace of aging

Actionalble Coaching to improve your body's Momentum

Understand if you’re building momentum

Actionalble Coaching to improve your body's Momentum

Hume Pod Helps You Make the Right Ones.

Thousand of reviews from extraordinary people like you

FAQ

Hume Pod Helps You
Make the Right Ones.