{ "type": "slideout", "content": { "title": "45-Metric List", "content": "\u003cp\u003e\u003cstrong\u003eCore totals (20)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eWeight\u003c\/li\u003e\u003cli\u003eBMI\u003c\/li\u003e\u003cli\u003eBody Fat Rate (aka body fat %)\u003c\/li\u003e\u003cli\u003eBody Fat Percentage\u003c\/li\u003e\u003cli\u003eFat Mass\u003c\/li\u003e\u003cli\u003eMuscle Mass\u003c\/li\u003e\u003cli\u003eSkeletal Muscle Mass\u003c\/li\u003e\u003cli\u003eMuscle vs Fat Ratio\u003c\/li\u003e\u003cli\u003eVisceral Fat\u003c\/li\u003e\u003cli\u003eMetabolic Age\u003c\/li\u003e\u003cli\u003eBasal Metabolic Rate (BMR)\u003c\/li\u003e\u003cli\u003eHydration (status\/level)\u003c\/li\u003e\u003cli\u003eWater Weight\u003c\/li\u003e\u003cli\u003eTotal Body Water (TBW)\u003c\/li\u003e\u003cli\u003eIntracellular Water (ICW)\u003c\/li\u003e\u003cli\u003eExtracellular Water (ECW)\u003c\/li\u003e\u003cli\u003eProtein Levels\u003c\/li\u003e\u003cli\u003eBone mineral content \/ “bone” metric (often marketed as bone density)\u003c\/li\u003e\u003cli\u003eHeart health \u003c\/li\u003e\u003cli\u003eFull-body segmental scan coverage (arms\/torso\/legs)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental fat % (5)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Fat %\u003c\/li\u003e\u003cli\u003eLeft Arm Fat %\u003c\/li\u003e\u003cli\u003eTrunk Fat %\u003c\/li\u003e\u003cli\u003eRight Leg Fat %\u003c\/li\u003e\u003cli\u003eLeft Leg Fat %\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/lean outputs (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eTrunk Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/water balance ratings (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eTorso Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Water Balance %\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental intracellular-water health (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eTorso ICW health (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg ICW health (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eScoring + insights shown in creative (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eOverall Health Score\u003c\/li\u003e\u003cli\u003eBody Composition Grade\u003c\/li\u003e\u003cli\u003eActivity Grade\u003c\/li\u003e\u003cli\u003eSleep Grade\u003c\/li\u003e\u003cli\u003eRight-vs-left limb difference flag (lean\/muscle asymmetry callout)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e" }, "width": 750, "transitionDuration": 150 }

{ "type": "slideout", "content": { "title": "11-modal", "content": "\u003ch4\u003eLean Mass Preservation During GLP‑1-Assisted Weight Loss in Engaged Digital Health Program Participants\u003c\/h4\u003e\n\u003cp\u003e\u003ci\u003eAn Outcomes Analysis of 6,990 Hume Health Premium Members\n \u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eHume Health Corp • Internal Outcomes Analysis • 2024\n Correspondence: research@humehealth.com • Methodology available on request\n\u003c\/p\u003e\n\u003ch4\u003eABSTRACT\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003eBackground.\u003c\/b\u003e GLP‑1 receptor agonists produce substantial weight loss but are associated with lean mass loss of\n 25–39%\n of total weight lost in published clinical trials. Lean mass is a primary determinant of resting metabolic rate, and\n its loss during weight reduction is associated with impaired weight maintenance following treatment cessation. This\n analysis examined lean mass outcomes in a real-world cohort of Hume Health premium platform members who met defined\n engagement criteria.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMethods.\u003c\/b\u003e Retrospective analysis of 6,990 Hume Health premium members on GLP‑1 therapy who completed a minimum\n of\n three body composition measurements per week via the Hume Body (8-sensor bioelectrical impedance analysis) and made\n weekly attestations of adherence to Pro.f AI protocol guidance. Body composition was measured at each weigh-in. The\n primary outcome was lean mass loss as a percentage of total weight lost, assessed from highest recorded weight (peak)\n to lowest recorded weight (nadir). Weighted mean lean mass loss was computed as the ratio of aggregate lean mass\n change to aggregate total weight lost across the full cohort.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eResults.\u003c\/b\u003e Mean baseline weight was 105.3 kg (SD 21.8). Mean total weight lost was 21.9 kg (SD 6.8),\n representing 21.3%\n of baseline body weight. The weighted mean lean mass loss as a percentage of total weight lost was 16.9%. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 12.7% of members preserved or increased lean\n mass over the measurement period. Among the 87.3% of members who lost lean mass, mean lean mass loss as a percentage\n of total weight lost was 22.0%.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\n Conclusions. \u003c\/b\u003e Hume Health premium members on GLP‑1 therapy demonstrated lean mass loss substantially below the\n 25–39%\n range documented in published clinical trials. These results are consistent with the hypothesis that\n high-frequency\n body composition monitoring combined with AI-guided protocol adherence supports favorable body composition\n outcomes\n during medically assisted weight loss.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKeywords:\u003c\/b\u003e \u003ci\u003eGLP‑1 receptor agonists; lean mass preservation; body composition; semaglutide; weight loss;\n bioelectrical impedance analysis; digital health\u003c\/i\u003e\u003c\/p\u003e\n \n\u003ch4\u003e1. INTRODUCTION\u003c\/h4\u003e\n\u003cp\u003eGlucagon-like peptide-1 (GLP‑1) receptor agonists represent a substantial advance in pharmacological obesity\n management. In the STEP 1 clinical trial, once-weekly subcutaneous semaglutide 2.4 mg produced mean total body weight\n loss of 14.9% over 68 weeks, compared to 2.4% in the placebo group receiving lifestyle intervention alone —\n approximately 6.2 times greater weight loss than lifestyle intervention alone.¹\u003c\/p\u003e\n\u003cp\u003eHowever, a consistent finding across GLP‑1 clinical trials is that a meaningful proportion of weight lost derives\n from lean tissue rather than adipose tissue. Neeland et al. documented lean mass reductions of 40–60% of total weight\n lost in some GLP‑1 trial cohorts, with substantial heterogeneity across studies.² Prado et al., in a commentary in The\n Lancet Diabetes \u0026 Endocrinology, reported lean mass loss of 25–39% of total weight lost across medically induced\n weight loss programs.³\u003c\/p\u003e\n\u003cp\u003eThis is clinically significant because skeletal muscle mass is a primary determinant of resting metabolic rate (RMR)\n — the baseline energy expenditure that determines whether a patient can sustain their new body weight after treatment\n ends.⁶ In the STEP 1 extension trial, participants who discontinued semaglutide without a structured metabolic exit\n protocol regained two-thirds of their prior weight loss within one year of stopping treatment.⁴\u003c\/p\u003e\n\u003cp\u003eThe Hume Health platform combines GLP‑1 therapy with high-frequency body composition measurement via bioelectrical\n impedance analysis (BIA), physician oversight informed by longitudinal tissue-level data, and an AI guidance system\n (Pro.f) that surfaces body composition patterns for clinical review and member adherence. This analysis examines\n whether this protocol-supported approach is associated with lean mass outcomes below published benchmarks.\n\u003c\/p\u003e\n \n\u003ch4\u003e2. METHODS\n\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e2.1 Study Design\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis was a retrospective cohort analysis of real-world member data from the Hume Health platform. The analysis period\n spanned active program enrollment through March 2026. The study was conducted under Hume Health Corp internal data\n governance protocols. Member data were de-identified prior to analysis. The study did not constitute human subjects\n research requiring institutional review board oversight under 45 CFR 46 as it involved retrospective analysis of\n de-identified operational data.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.2 Participants\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eEligible participants were Hume Health premium members who: (1) were actively enrolled in a GLP‑1 therapy program\n during the analysis period; (2) completed a minimum of three Hume Body body composition measurements per week\n throughout the measurement window; and (3) completed weekly attestations confirming engagement with and adherence to\n Pro.f AI protocol guidance. Members who did not meet all three criteria were excluded from analysis.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.3 Measurements\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBody weight and body composition were measured at each weigh-in using the Hume Pod, a bioelectrical impedance analysis\n device measuring whole-body and segmental lean mass, fat mass, and total body water. BIA measurements were recorded at\n consistent times relative to weigh-in. Lean mass at peak weight (highest recorded body weight during the measurement\n window) and lean mass at nadir weight (lowest recorded body weight) were identified for each member. Lean mass delta\n was computed as lean mass at nadir minus lean mass at peak. Weight loss was computed as peak weight minus nadir\n weight.\n\u003c\/p\u003e\n\u003cp\u003eLean mass loss as a percentage of total weight lost was computed for each member as: (|lean mass delta| \/ weight\n loss) × 100, where lean mass delta was negative for members who lost lean mass and positive for members who preserved\n or gained lean mass. The primary aggregate outcome — weighted mean lean mass loss as a percentage of total weight lost\n — was computed as: (sum of lean mass deltas across all members \/ sum of total weight lost across all members) × 100,\n reflecting the population-level ratio of lean mass change to total weight change.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.4 Statistical Analysis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDescriptive statistics were computed for all primary and secondary outcomes. Continuous variables are reported as\n mean (standard deviation) and median. The weighted mean was used as the primary outcome measure for lean mass loss as\n a percentage of total weight lost, as it accounts for variation in total weight lost across members and reflects the\n aggregate population-level body composition response. Members who preserved or gained lean mass during the measurement\n period (lean mass delta ≥ 0) are included in all analyses; their inclusion in the weighted mean computation reduces\n the aggregate lean mass loss percentage relative to analyses restricted to members with lean mass loss.\u003c\/p\u003e\n\u003ch4\u003e3. RESULTS\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e3.1 Participant Characteristics\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA total of 6,990 members met all eligibility criteria and were included in the analysis. Baseline characteristics are\n presented in Table 1.\u003c\/p\u003e\n \n\u003cdiv class=\"table_drawer\"\u003e\n \u003cp\u003eTable 1. Baseline Participant Characteristics (n = 6,990)\u003c\/p\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eCharacteristic\u003c\/th\u003e\n \u003cth\u003eValue\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eSample size (n)\u003c\/td\u003e\n \u003ctd\u003e6,990\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean baseline weight, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e105.3 (21.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian baseline weight, kg\u003c\/td\u003e\n \u003ctd\u003e102.3\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMeasurement frequency (minimum)\u003c\/td\u003e\n \u003ctd\u003e3 weigh-ins per week\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eProof engagement attestation\u003c\/td\u003e\n \u003ctd\u003eWeekly (required for inclusion)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.2 Weight Loss Outcomes\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eMean total weight lost was 21.9 kg (SD 6.8), representing a mean reduction of 21.3% (SD 6.7%) of baseline body\n weight. Median weight lost was 19.6 kg, representing 20.0% of baseline body weight. Weight loss outcomes are presented\n in Table 2.\u003c\/p\u003e\n \n\u003cp\u003eTable 2. Weight Loss Outcomes\u003c\/p\u003e\n\u003cdiv class=\"table_drawer2\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e21.9 (6.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e19.6\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, % of baseline (SD)\u003c\/td\u003e\n \u003ctd\u003e21.3% (6.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, % of baseline\u003c\/td\u003e\n \u003ctd\u003e20.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMinimum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e15.7\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMaximum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e75.4\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cb\u003e3.3 Lean Mass Outcomes\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean lean mass loss as a percentage of total weight lost was 16.9% across all 6,990 members. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 890 members (12.7%) preserved or increased\n lean mass over the measurement period (lean mass delta ≥ 0). Among the 6,100 members (87.3%) who lost lean mass, the\n mean lean mass loss as a percentage of total weight lost was 22.0%. Lean mass outcomes are presented in Table 3.\u003c\/p\u003e\n \n\u003cp\u003eTable 3. Lean Mass Outcomes\u003c\/p\u003e\n\u003cdiv class=\"table_drawer3\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eWeighted mean lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e16.9%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e19.4%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers preserving or gaining lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e890 (12.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers losing lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e6,100 (87.3%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean lean mass loss, % of total weight lost (among those with lean mass loss)\u003c\/td\u003e\n \u003ctd\u003e22.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003ePublished benchmark (Prado et al., 2024; Neeland et al., 2024)\u003c\/td\u003e\n \u003ctd\u003e25–39% (range across GLP-1 trials)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.4 Interpretation of the Weighted Mean Outcome\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean of 16.9% reflects the aggregate population-level ratio of total lean mass change to total weight\n lost across all members. Because members who preserved or gained lean mass (12.7% of the cohort) contribute negative\n lean mass loss values to the numerator, the weighted mean is lower than the mean computed among members who lost lean\n mass exclusively (22.0%). Both measures are reported to provide transparency regarding cohort composition. The\n weighted mean is the primary outcome because it most accurately represents the population-level body composition\n impact of the program.\u003c\/p\u003e\n\u003ch4\u003e4. DISCUSSION\n\u003c\/h4\u003e\n\u003cp\u003eThis analysis demonstrates that Hume Health premium members on GLP‑1 therapy, who met defined body composition\n monitoring and AI protocol engagement criteria, experienced lean mass loss substantially below the benchmarks\n documented in published GLP‑1 clinical trials. The weighted mean lean mass loss of 16.9% of total weight lost compares\n favorably to the 25–39% range reported by Prado et al.³ and the 40–60% upper range reported in some cohorts by Neeland\n et al.²\n\u003c\/p\u003e\n\u003cp\u003eThe mechanism by which frequent body composition measurement and protocol-guided engagement may attenuate lean mass\n loss is consistent with established physiology. Skeletal muscle mass is the primary determinant of resting metabolic\n rate.⁶ Interventions that preserve lean mass during caloric restriction — including higher protein intake, resistance\n exercise, and dose calibration timed to body composition response — are documented to reduce lean mass loss during\n weight reduction. The Hume platform protocol facilitates tissue-level visibility that enables these calibrations in\n near real-time; the present analysis cannot isolate which components of the program contributed to the observed\n outcomes.\n\u003c\/p\u003e\n\u003cp\u003eThe finding that 12.7% of members preserved or gained lean mass during GLP‑1-assisted weight loss is notable. This\n subgroup is likely influenced by favorable baseline characteristics, behavioral factors, and variability in BIA\n measurement across conditions, and should not be interpreted as a program-level guarantee of lean mass preservation.\n Its inclusion in the weighted mean reduces the reported aggregate lean mass loss figure relative to analyses\n restricted to members who lost lean mass.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.1 Limitations\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis has several limitations that should be considered when interpreting results. First, the study is\n retrospective and observational, without a concurrent control group. Comparison to published clinical trial benchmarks\n involves differences in population, measurement methodology, and GLP‑1 agent. Second, body composition was measured\n via bioelectrical impedance analysis rather than dual-energy X-ray absorptiometry (DXA) or magnetic resonance imaging\n (MRI), which are considered the reference standards for lean mass quantification. BIA measurements are sensitive to\n hydration status, time of measurement, and device calibration, and may produce systematic differences relative to\n DXA-derived lean mass values. Third, the cohort consists of premium-tier members who met a minimum engagement\n threshold; results may not generalize to members with lower engagement frequency or to non-engaged GLP‑1 users.\n Fourth, no information on dietary protein intake, resistance exercise participation, or specific GLP‑1 agent and\n dosing schedule was incorporated into this analysis, and these variables are likely to influence lean mass outcomes.\n Fifth, the duration of the measurement window varied across members and was determined by the interval between peak\n and nadir weight rather than a fixed protocol period.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.2 Future Directions\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eProspective controlled study designs with standardized measurement protocols, dietary and exercise co-variate\n capture, and DXA-validated BIA calibration would provide stronger evidence for the role of high-frequency monitoring\n and AI-guided adherence in lean mass preservation during GLP‑1 therapy. Subgroup analyses examining the impact of\n engagement frequency, protein intake, resistance training participation, and GLP‑1 agent on lean mass outcomes would\n further characterize the mechanisms underlying these findings.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5. CONCLUSIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAmong 6,990 Hume Health premium members on GLP‑1 therapy who met defined body composition monitoring and AI protocol\n engagement criteria, the weighted mean lean mass loss as a percentage of total weight lost was 16.9%. This is\n substantially below the 25–39% range reported in published GLP‑1 clinical trial literature. The median lean mass loss\n was 19.4%. These findings are consistent with the hypothesis that high-frequency tissue-level monitoring, combined\n with AI-guided protocol adherence and physician oversight informed by body composition data, supports favorable lean\n mass outcomes during medically assisted weight loss. Prospective controlled research is needed to confirm these\n findings and to isolate the active components of the platform protocol.\n\u003c\/p\u003e\n \n\u003ch4\u003eREFERENCES\u003c\/h4\u003e\n \n\u003cp\u003e1. Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl\n J Med. 2021;384(11):989–1002. doi:10.1056\/NEJMoa2032183.\u003c\/p\u003e\n\u003cp\u003e2. Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and\n mitigation strategies. Diabetes Obes Metab. 2024;26(Suppl 4):16–27. doi:10.1111\/dom.15728.\u003c\/p\u003e\n\u003cp\u003e3. Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB. Muscle matters: the effects of medically induced weight loss on\n skeletal muscle. Lancet Diabetes Endocrinol. 2024;12(11):785–787. doi:10.1016\/S2213-8587(24)00272-9.\u003c\/p\u003e\n\u003cp\u003e4. Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of\n semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–1564. doi:10.1111\/dom.14725.\u003c\/p\u003e\n\u003cp\u003e5. Hume Health Corp. Lean Mass Preservation in GLP‑1 Members: An Internal Outcomes Analysis. 2024. Analysis of 6,990\n premium members. Methodology available on request: research@humehealth.com.\n\u003c\/p\u003e\n\u003cp\u003e6. Ravussin E, Bogardus C. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Appl\n Physiol. 1989;66(3). PMID:2243122.\n\u003c\/p\u003e\n \n\u003cp\u003e\u003cb\u003eDisclosure Statement\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis was conducted by Hume Health Corp using data from the Hume Health platform. Hume Health Corp is the\n developer of the body composition monitoring hardware (Hume Body Pod) and AI guidance system (Pro.f) evaluated in this\n analysis. No external funding was received. The analysis has not undergone independent peer review. Investigators have\n an inherent commercial interest in the outcomes described.\u003c\/p\u003e" }, "width": 750, "transitionDuration": 150 }

As seen in

Are Your Habits Aging You Faster or Slower? 7 Reasons the Hume Band Shows You

You cannot slow what you cannot see. A screenless band, bought once, makes your aging curve visible.

Your body keeps score of every late night and every early one. The Hume Band reads that score around the clock, from recovery, HRV and sleep to blood-pressure trend insights and your Pace of Aging, then shows you the direction it is all heading. No screen. No subscription. Here are the seven reasons people who take aging seriously wear it.

Watch your Pace of Aging move
Bought once, never billed again
45 days to watch it on your own wrist

4.7★: 2,955 verified reviews
24/7: Biomarker tracking
$0/mo: No subscription

See the 7 Reasons ↓ Get Yours & Save 30%

1/10

Reason 1

It shows you which way you're aging, not how many steps you took

Pace of Aging

32yrs

Biological Age

YoungerOlder

Chronological Age 45 yrs

Directional estimate, moves with your habits.

Every habit you have is pushing your body in one of two directions. Six hours of sleep, the skipped walk, the early night: each one nudges you toward aging faster or aging slower. The Band tracks your Pace of Aging, a directional estimate of how fast your body is aging and where it is heading, paired with Metabolic Momentum, a daily read on your trajectory.

A single reading is noise. The trend is the signal. Watch that number respond over weeks as you fix your sleep or drop the nightcap, and aging well stops being an abstraction and becomes a feedback loop. It is an estimate, not a diagnosis, and it moves with your habits.

Pace of Aging

32yrs

Biological Age

YoungerOlder

Chronological Age 45 yrs

Directional estimate, moves with your habits.

Reason 2

No screen, no guesswork: it reads your biomarkers around the clock

Fair question: how does a $249 band with no screen know any of this? It is not counting steps and guessing the rest. An optical sensor array reads your biomarkers directly: HRV, resting heart rate, blood oxygen, skin temperature and sleep stages, all day and all night.

Hume's AI turns those thousands of daily readings into the scores that matter for how you age: recovery, Metabolic Momentum, your Pace of Aging. And every signal carries its own confidence rating, so when a reading is shaky the app says so instead of pretending. Most wearables hide that uncertainty. This one puts it on the tile.

Hume Band 2.0

$293~~$419~~Save 30%

No subscription · 45-day home trial

Get the Hume Band

Reason 3

Blood-pressure trend insights between doctor visits, not once a year

Blood Pressure

130/89mmHg

Last: Mon

SMTWTFS

Directional trend, not a diagnosis.

Trusted by Dr. Yaz Dominguez Board-certified Family Medicine, DO@doctor_yaz

Most people meet their blood pressure once a year, in a doctor's office, as a single number taken at one random moment. The Band gives you blood-pressure trend insights from your wrist instead: how your patterns shift across days and weeks, connected to the stressful quarter, the salty vacation or the stretch of bad sleep behind them.

One owner told us that watching her trend for a few weeks is what finally got her to bring it up with her doctor. To be precise about what this is: trend insights, not a cuff replacement, and never a diagnosis. For medical readings and decisions, use a validated cuff and talk to your healthcare provider.

Blood Pressure

130/89mmHg

Last: Mon

SMTWTFS

Directional trend, not a diagnosis.

Trusted by Dr. Yaz Dominguez Board-certified Family Medicine, DO@doctor_yaz

Reason 4

Sleep and recovery bend the curve. Now you can watch them do it.

Recommended by Dr. Seth Capehart Emergency Medicine, MD

If the aging curve has levers, they are sleep and recovery. Both are measurable: how your HRV rebounds overnight, where your resting heart rate settles, how much deep and REM sleep you actually got. Every morning the Band hands you a recovery score built from that night, so you know whether today is a day to push or to back off.

Within a few weeks the cause and effect gets almost uncomfortably clear. Two glasses of wine show up in tomorrow's recovery. A consistent bedtime shows up in the trend a month later. And because the Band runs about two weeks per charge, it never sleeps on a charger and never misses the night where all of this data lives.

Recommended by Dr. Seth Capehart Emergency Medicine, MD

Hume Band 2.0

$293~~$419~~Save 30%

No subscription · 45-day home trial

Get the Hume Band

Reason 5

The math: $249 once, while Whoop and Oura bill you every single year

The 2-year cost

Own it once.
It never stops working.

$249

Hume Band

once

$697+

Whoop

membership

$438+

Oura

ring + membership

No subscription. Ever.

2-year cost, based on published pricing.

Here is the quiet problem with the other longevity wearables: they charge you rent. Whoop requires a membership of $199 to $359 a year and stops working when you stop paying. Oura sells you a $349 to $499 ring, then locks your daily scores and HRV trends behind another $69.99 a year.

Run that math on the timescale longevity actually happens on. Three years of Whoop membership alone is roughly $600 to $1,080. The Hume Band is $249 once, down from $356, and your core scores and data stay free forever. There is an optional Premium tier for deeper coaching, and you never need it.

Whoop: $199 to $359 a year. Oura: $69.99 a year plus the ring. Hume Band: $0 a year, forever.

The 2-year cost

Own it once.
It never stops working.

$249

Hume Band

once

$697+

Whoop

membership

$438+

Oura

ring + membership

No subscription. Ever.

2-year cost, based on published pricing.

What Hume Owners Say

Daniel K. Verified

"Metabolic Momentum became something I check each morning. HRV drops predictably after poor sleep or a glass of wine, and it lines up with how I feel."

Priya S. Verified

"Watching the blood-pressure trend over a few weeks finally pushed me to talk to my doctor. Loved having the pattern in front of me."

Myriam Z. Verified

"Switched from Whoop and I much, much prefer the Hume Band. No monthly fee and it still tells me everything I actually used Whoop for."

4.7 · 2,955 verified reviews

Reason 6

Built to still be on your wrist next year, not in the drawer

Every drawer has a dead wearable in it. Not because the tech failed, but because the habit did: the screen lighting up at dinner, the buzz in a meeting, the nightly charge that broke the streak. A device you abandon by March tells you nothing about how you are aging by December.

The Band is designed for the long game. No screen, no notifications, no dopamine loop on your wrist. The soft UltraLux strap is light enough that most people forget it is on, through the workday and through the night, and charging is a twice-a-month event. The data only compounds if the band stays on.

Up to 14 days per charge. Screenless, with no notifications to silence.

Reason 7

45 days at home to feel the difference, at 30% off

Hume Band 2.0 in its box, own it once for $293, was $419

Limited time offer --:--:-- Own it once. No subscription.

Own it once $293 ~~$419~~−30% 45-day at-home trial · free shipping · no subscription

A trend takes weeks to mean anything, which is exactly why a seven-day return window on a wearable is a joke. Hume gives you 45 days at home. That is six weeks of real life: workouts, deadlines, bad nights, one questionable weekend. Long enough to watch your first month of direction build.

If what you see is not worth it, send it back for a full refund. Shipping is free, and there is no subscription quietly billing you while you decide. 2,955 people have already run this experiment and rated it 4.7 stars. The trial means you get that look without the bet.

Limited time offer --:--:-- Own it once. No subscription.

Own it once $293 ~~$419~~−30% 45-day at-home trial · free shipping · no subscription

Get the Hume Band 2.0

Start bending your aging curve this week

Your Pace of Aging trend starts building from the first night. One-time $249, was $356, with a 45-day at-home trial and free shipping.

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48,252+ Reviews

The Hume Band

Shop Now

The Hume Band isn’t another tracker

Hume shows you what’s happening inside your body — not just how hard you worked.

Comparison

Hume Band

Others

Focus

Longevity, disease detection,
healthspan

Strain, recovery, athletic
performance, lifespan limited to
premium*

Data Ownership

You own your health
data (exportable)

You don’t own your
data (locked behind membership)

Subscription
Required?

No, One time purchase
with option to upgrade to premium

Yes - $30/month (or more)

Body Composition
Tracking

Yes, via Hume Pod

Digital Twin / AI
insights

Yes, future-ready
predictive insights

No (basic insights only)

Holistic Health
Coaching

Yes, Science-backed, longevity-
focused

Limited to performance/recovery tips

Longevity Metrics
(HRV, Resilience)

Yes, with longevity index,
metabolic momentum
and capacity

HRV only

Price

One-time purchase: $199-$249 (no
subscription)

$300-480/year (ongoing)

Your True Age

Coaching That Targets Aging — Not Just Strain

Other trackers focus on workouts and recovery.

Hume is a full longevity system — with tools for disease detection, aging, and health optimization.

Biological Age is a label.

Metabolic Capacity is a system.

Hume says:

Hume says:
“Your momentum is 82. You gained 3.2 days of life last week — here’s how to gain more.”

Others say:

Others say:
“You’re biologically 37.”

We don’t just tell you how old you are.
We help you get younger — and prove it

Lifetime Access

No Monthly Fees to Access Your Own Health

Hume:

Hume: One-time purchase. Premium
optional*

Others:

Others: $30/month just to see
your data.

We believe your health data shouldn’t be locked behind a subscription.
With Hume Band, you own the device — and your insights. Forever.

Longevity

Real Longevity Metrics — Not Just HRV

Hume:

Hume: Metabolic Momentum, Capacity,
Resilience, and a full Longevity Index.

Others:

Others: Just lifespan. HRV is one
piece of the puzzle.

Hume gives you the whole picture — and shows how your body is actually changing over time.

Know Your Body

Direct Measurement — Not Just Inference

Others guess aging from HRV, sleep, and heart rate.

Hume measures it — directly.

The Hume Band + Hume Pod track real biomarkers in fat, muscle, and tissue — where aging actually
happens.

Inference is helpful.

But direct data is powerful.

Excellent | 5.0 reviews

How has Hume Band 2.0 helped people reach their goals?

“As a doctor, I’m impressed Most of my patients come in wanting a "magic pill" for longevity, but the truth is, daily habits matter more than anything. That’s why I was thrilled to discover the Hume Band. Unlike other wearables that focus on generic metrics, it tracks metabolic capacity—a key indicator of cellular health and aging. The data is presented in a way that’s accessible (no medical degree required!), and I’ve started recommending it to patients who want to take control of their health. One diabetic patient even reduced his insulin resistance by 20% after using the band’s insights to tweak his exercise and meal timing. For anyone serious about preventive health, this is a game-changer.

Brooklyn

Verified Member

“I can’t say enough good things about the Hume Band. One of the most impressive features for me has been the Metabolic Capacity. It flagged signs of strain on my body before I even realized something was wrong—turns out I had a chest infection! Thanks to the early warning, I was able to get checked out and start treatment before things got worse. The Band itself is super comfortable to wear all day and night. It gives me detailed insights on how my habit is impacting my energy levels and how to increase my metabolic capacity, and now I truly listen to what my body needs. The app is really intuitive, and the health data feels incredibly personalized and accurate. If you’re looking for a smart health tracker that goes beyond tracking fitness and sleep, the Hume Band is the one. I genuinely feel more in tune with my health, and in this case, it may have even helped me catch a serious issue early. Highly recommended!

Savannah

Verified Member

“I bought this on a whim—now I can’t imagine life without it. I wasn’t sure what to expect, but the Hume Band has become my daily health coach. It tracks things I didn’t even know mattered (like metabolic momentum) and shows me exactly how my choices affect my body. The app is sleek and user-friendly, and I love the weekly reports. My partner saw my results and ordered one for himself—now we’re both hooked!

Jenny

Verified Member

“I’ve tried every health tracker out there, and the Hume Band is in a league of its own. Most wearables just count steps or monitor heart rate, but the Hume Band goes deeper—tracking metabolic momentum and capacity to show how my daily habits impact my long-term health. The app breaks everything down in a way that’s easy to understand, and I’ve already made small tweaks (like adjusting my meal timing and sleep routine) that have had a huge impact on my energy. If you’re serious about longevity, this is a must.

Emily

Verified Member

Frequently Asked Questions

What is the difference between Band 1.0 and Band 2.0?

Improved accuracy
Better signal processing means more reliable health insights and clearer trends over time.
Blood pressure trends tracking
Instead of isolated readings, 2.0 shows how your blood pressure changes across days and habits.
14-day battery life
Wear it longer, charge it less. Built for uninterrupted health tracking.
UltraLux strap
A more premium, comfortable, all-day wearable design.
Nutrition tracking (coming June)
Soon you'll be able to connect food intake with your body's response for deeper health insights.

What raw data does the Hume Band track and measure?

Continuous heart rate monitoring
Heart Rate Variability (HRV)
Blood oxygen levels (SpO2)
Sleep stages (light, deep, REM, awake)
Sleep quality and efficiency
Activity levels and movement patterns
Strain and recovery
Skin temperature
Blood Pressure Insights (NEW)

What is “longevity,” and how does the Hume Band support it?

Longevity means living a longer, healthier life—free from preventable diseases. The Hume Band helps by continuously tracking and interpreting signals from your body to:

Spot early signs of imbalance or chronic risk
Monitor how daily habits impact your aging process
Provide insights to improve healthspan—not just lifespan

On average, Hume Band users gained an extra 39 days of life in their first year with Hume

Our tools are designed to help you make small changes that compound into big results over time.

Do I need a subscription to use the Band?

No subscription is required to use the Band or access your raw data.

However, if you'd like AI-driven insights, personalized longevity coaching, and deep health analysis, you can subscribe to Hume Premium starting at $8.99/month. This supports the computing power needed to deliver real-time, intelligent health feedback.

Is the Band waterproof or sweatproof?

Yes. The Hume Band is IP68-rated—meaning it's:

Dustproof
Water-resistant up to 1 meter (3.2 feet) for up to 2 hours

Perfect for showers, swimming, and workouts—no interruptions.

What is the battery life of the Hume Band?

Up to 14 days of battery life with typical use
Fast charging: Full charge in approximately 30 minutes

Note: Frequent syncing and continuous tracking may slightly reduce battery life.

Is the Band compatible with my phone?

Yes. The Hume Band works with:

iOS Devices

iPhone 8 and newer
iOS 14.0 and above

Android Devices

Android 8.0 (Oreo) and above

Can I buy the Band without the Hume Pod?

Yes. The Hume Band works perfectly on its own for daily tracking.

The Hume Pod is an optional companion device that scans your body composition (body fat, muscle mass, etc.) for a more complete health picture—but it's not required.

What’s your return or exchange policy?

We offer a 45-day, no-questions-asked return or exchange policy. Return shipping costs apply.

Is my health data secure?

Yes. Your health data is:

Encrypted end-to-end
Stored on HIPAA-compliant servers
Only accessible to you (or your authorized providers if you choose)

We prioritize your privacy and never sell your data. You’re in control at every step.

It shows you which way you're aging, not how many steps you took

No screen, no guesswork: it reads your biomarkers around the clock

Blood-pressure trend insights between doctor visits, not once a year

Sleep and recovery bend the curve. Now you can watch them do it.

The math: $249 once, while Whoop and Oura bill you every single year

Own it once.It never stops working.

Own it once.It never stops working.

Built to still be on your wrist next year, not in the drawer

45 days at home to feel the difference, at 30% off

Start bending your aging curve this week

The Hume Band

The Hume Band 2.0

Your body's early warning system

Choose your optional add-ons:

10-Year Warranty

Not satisfied within 45 days? Get a full refund

Looking for more information?

About the app

Difference between Band 1.0 and 2.0?

Technical specifications

FAQs

1. What raw data does the Hume Band track and measure?

2. What is “longevity,” and how does the Hume Band support it?

3. Do I need a subscription to use the Band?

4. Is the Band waterproof or sweatproof?

5. What is the battery life of the Hume Band?

6. What wrist sizes does the Band fit?

7. Is the Band compatible with my phone?

Can I buy the Band without the Hume Pod?

Shipping & returns

🏆 The Award-Winning Longevity Band

How has Hume Band 2.0 helped people reach their goals?

Frequently Asked Questions

What is the difference between Band 1.0 and Band 2.0?

What raw data does the Hume Band track and measure?

What is “longevity,” and how does the Hume Band support it?

Do I need a subscription to use the Band?

Is the Band waterproof or sweatproof?

What is the battery life of the Hume Band?

Is the Band compatible with my phone?

Can I buy the Band without the Hume Pod?

What’s your return or exchange policy?

Is my health data secure?

Own it once.
It never stops working.

Own it once.
It never stops working.