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{ "type": "slideout", "content": { "title": "45-Metric List", "content": "\u003cp\u003e\u003cstrong\u003eCore totals (20)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eWeight\u003c\/li\u003e\u003cli\u003eBMI\u003c\/li\u003e\u003cli\u003eBody Fat Rate (aka body fat %)\u003c\/li\u003e\u003cli\u003eBody Fat Percentage\u003c\/li\u003e\u003cli\u003eFat Mass\u003c\/li\u003e\u003cli\u003eMuscle Mass\u003c\/li\u003e\u003cli\u003eSkeletal Muscle Mass\u003c\/li\u003e\u003cli\u003eMuscle vs Fat Ratio\u003c\/li\u003e\u003cli\u003eVisceral Fat\u003c\/li\u003e\u003cli\u003eMetabolic Age\u003c\/li\u003e\u003cli\u003eBasal Metabolic Rate (BMR)\u003c\/li\u003e\u003cli\u003eHydration (status\/level)\u003c\/li\u003e\u003cli\u003eWater Weight\u003c\/li\u003e\u003cli\u003eTotal Body Water (TBW)\u003c\/li\u003e\u003cli\u003eIntracellular Water (ICW)\u003c\/li\u003e\u003cli\u003eExtracellular Water (ECW)\u003c\/li\u003e\u003cli\u003eProtein Levels\u003c\/li\u003e\u003cli\u003eBone mineral content \/ “bone” metric (often marketed as bone density)\u003c\/li\u003e\u003cli\u003eHeart health \u003c\/li\u003e\u003cli\u003eFull-body segmental scan coverage (arms\/torso\/legs)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental fat % (5)\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Fat %\u003c\/li\u003e\u003cli\u003eLeft Arm Fat %\u003c\/li\u003e\u003cli\u003eTrunk Fat %\u003c\/li\u003e\u003cli\u003eRight Leg Fat %\u003c\/li\u003e\u003cli\u003eLeft Leg Fat %\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/lean outputs (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eTrunk Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Lean (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental muscle\/water balance ratings (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Arm Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eTorso Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eRight Leg Muscle\/Water Balance %\u003c\/li\u003e\u003cli\u003eLeft Leg Muscle\/Water Balance %\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSegmental intracellular-water health (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eRight Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Arm ICW health (segmental)\u003c\/li\u003e\u003cli\u003eTorso ICW health (segmental)\u003c\/li\u003e\u003cli\u003eRight Leg ICW health (segmental)\u003c\/li\u003e\u003cli\u003eLeft Leg ICW health (segmental)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eScoring + insights shown in creative (5)\u003cbr\/\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003col\u003e\u003cli\u003eOverall Health Score\u003c\/li\u003e\u003cli\u003eBody Composition Grade\u003c\/li\u003e\u003cli\u003eActivity Grade\u003c\/li\u003e\u003cli\u003eSleep Grade\u003c\/li\u003e\u003cli\u003eRight-vs-left limb difference flag (lean\/muscle asymmetry callout)\u003cbr\/\u003e\u003c\/li\u003e\u003c\/ol\u003e" }, "width": 750, "transitionDuration": 150 }

{ "type": "slideout", "content": { "title": "11-modal", "content": "\u003ch4\u003eLean Mass Preservation During GLP‑1-Assisted Weight Loss in Engaged Digital Health Program Participants\u003c\/h4\u003e\n\u003cp\u003e\u003ci\u003eAn Outcomes Analysis of 6,990 Hume Health Premium Members\n \u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003eHume Health Corp • Internal Outcomes Analysis • 2024\n Correspondence: research@humehealth.com • Methodology available on request\n\u003c\/p\u003e\n\u003ch4\u003eABSTRACT\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003eBackground.\u003c\/b\u003e GLP‑1 receptor agonists produce substantial weight loss but are associated with lean mass loss of\n 25–39%\n of total weight lost in published clinical trials. Lean mass is a primary determinant of resting metabolic rate, and\n its loss during weight reduction is associated with impaired weight maintenance following treatment cessation. This\n analysis examined lean mass outcomes in a real-world cohort of Hume Health premium platform members who met defined\n engagement criteria.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMethods.\u003c\/b\u003e Retrospective analysis of 6,990 Hume Health premium members on GLP‑1 therapy who completed a minimum\n of\n three body composition measurements per week via the Hume Body (8-sensor bioelectrical impedance analysis) and made\n weekly attestations of adherence to Pro.f AI protocol guidance. Body composition was measured at each weigh-in. The\n primary outcome was lean mass loss as a percentage of total weight lost, assessed from highest recorded weight (peak)\n to lowest recorded weight (nadir). Weighted mean lean mass loss was computed as the ratio of aggregate lean mass\n change to aggregate total weight lost across the full cohort.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eResults.\u003c\/b\u003e Mean baseline weight was 105.3 kg (SD 21.8). Mean total weight lost was 21.9 kg (SD 6.8),\n representing 21.3%\n of baseline body weight. The weighted mean lean mass loss as a percentage of total weight lost was 16.9%. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 12.7% of members preserved or increased lean\n mass over the measurement period. Among the 87.3% of members who lost lean mass, mean lean mass loss as a percentage\n of total weight lost was 22.0%.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\n Conclusions. \u003c\/b\u003e Hume Health premium members on GLP‑1 therapy demonstrated lean mass loss substantially below the\n 25–39%\n range documented in published clinical trials. These results are consistent with the hypothesis that\n high-frequency\n body composition monitoring combined with AI-guided protocol adherence supports favorable body composition\n outcomes\n during medically assisted weight loss.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKeywords:\u003c\/b\u003e \u003ci\u003eGLP‑1 receptor agonists; lean mass preservation; body composition; semaglutide; weight loss;\n bioelectrical impedance analysis; digital health\u003c\/i\u003e\u003c\/p\u003e\n \n\u003ch4\u003e1. INTRODUCTION\u003c\/h4\u003e\n\u003cp\u003eGlucagon-like peptide-1 (GLP‑1) receptor agonists represent a substantial advance in pharmacological obesity\n management. In the STEP 1 clinical trial, once-weekly subcutaneous semaglutide 2.4 mg produced mean total body weight\n loss of 14.9% over 68 weeks, compared to 2.4% in the placebo group receiving lifestyle intervention alone —\n approximately 6.2 times greater weight loss than lifestyle intervention alone.¹\u003c\/p\u003e\n\u003cp\u003eHowever, a consistent finding across GLP‑1 clinical trials is that a meaningful proportion of weight lost derives\n from lean tissue rather than adipose tissue. Neeland et al. documented lean mass reductions of 40–60% of total weight\n lost in some GLP‑1 trial cohorts, with substantial heterogeneity across studies.² Prado et al., in a commentary in The\n Lancet Diabetes \u0026 Endocrinology, reported lean mass loss of 25–39% of total weight lost across medically induced\n weight loss programs.³\u003c\/p\u003e\n\u003cp\u003eThis is clinically significant because skeletal muscle mass is a primary determinant of resting metabolic rate (RMR)\n — the baseline energy expenditure that determines whether a patient can sustain their new body weight after treatment\n ends.⁶ In the STEP 1 extension trial, participants who discontinued semaglutide without a structured metabolic exit\n protocol regained two-thirds of their prior weight loss within one year of stopping treatment.⁴\u003c\/p\u003e\n\u003cp\u003eThe Hume Health platform combines GLP‑1 therapy with high-frequency body composition measurement via bioelectrical\n impedance analysis (BIA), physician oversight informed by longitudinal tissue-level data, and an AI guidance system\n (Pro.f) that surfaces body composition patterns for clinical review and member adherence. This analysis examines\n whether this protocol-supported approach is associated with lean mass outcomes below published benchmarks.\n\u003c\/p\u003e\n \n\u003ch4\u003e2. METHODS\n\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e2.1 Study Design\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis was a retrospective cohort analysis of real-world member data from the Hume Health platform. The analysis period\n spanned active program enrollment through March 2026. The study was conducted under Hume Health Corp internal data\n governance protocols. Member data were de-identified prior to analysis. The study did not constitute human subjects\n research requiring institutional review board oversight under 45 CFR 46 as it involved retrospective analysis of\n de-identified operational data.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.2 Participants\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eEligible participants were Hume Health premium members who: (1) were actively enrolled in a GLP‑1 therapy program\n during the analysis period; (2) completed a minimum of three Hume Body body composition measurements per week\n throughout the measurement window; and (3) completed weekly attestations confirming engagement with and adherence to\n Pro.f AI protocol guidance. Members who did not meet all three criteria were excluded from analysis.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.3 Measurements\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBody weight and body composition were measured at each weigh-in using the Hume , a bioelectrical impedance analysis\n device measuring whole-body and segmental lean mass, fat mass, and total body water. BIA measurements were recorded at\n consistent times relative to weigh-in. Lean mass at peak weight (highest recorded body weight during the measurement\n window) and lean mass at nadir weight (lowest recorded body weight) were identified for each member. Lean mass delta\n was computed as lean mass at nadir minus lean mass at peak. Weight loss was computed as peak weight minus nadir\n weight.\n\u003c\/p\u003e\n\u003cp\u003eLean mass loss as a percentage of total weight lost was computed for each member as: (|lean mass delta| \/ weight\n loss) × 100, where lean mass delta was negative for members who lost lean mass and positive for members who preserved\n or gained lean mass. The primary aggregate outcome — weighted mean lean mass loss as a percentage of total weight lost\n — was computed as: (sum of lean mass deltas across all members \/ sum of total weight lost across all members) × 100,\n reflecting the population-level ratio of lean mass change to total weight change.\n\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.4 Statistical Analysis\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDescriptive statistics were computed for all primary and secondary outcomes. Continuous variables are reported as\n mean (standard deviation) and median. The weighted mean was used as the primary outcome measure for lean mass loss as\n a percentage of total weight lost, as it accounts for variation in total weight lost across members and reflects the\n aggregate population-level body composition response. Members who preserved or gained lean mass during the measurement\n period (lean mass delta ≥ 0) are included in all analyses; their inclusion in the weighted mean computation reduces\n the aggregate lean mass loss percentage relative to analyses restricted to members with lean mass loss.\u003c\/p\u003e\n\u003ch4\u003e3. RESULTS\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e3.1 Participant Characteristics\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA total of 6,990 members met all eligibility criteria and were included in the analysis. Baseline characteristics are\n presented in Table 1.\u003c\/p\u003e\n \n\u003cdiv class=\"table_drawer\"\u003e\n \u003cp\u003eTable 1. Baseline Participant Characteristics (n = 6,990)\u003c\/p\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eCharacteristic\u003c\/th\u003e\n \u003cth\u003eValue\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eSample size (n)\u003c\/td\u003e\n \u003ctd\u003e6,990\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean baseline weight, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e105.3 (21.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian baseline weight, kg\u003c\/td\u003e\n \u003ctd\u003e102.3\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMeasurement frequency (minimum)\u003c\/td\u003e\n \u003ctd\u003e3 weigh-ins per week\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eProof engagement attestation\u003c\/td\u003e\n \u003ctd\u003eWeekly (required for inclusion)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.2 Weight Loss Outcomes\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eMean total weight lost was 21.9 kg (SD 6.8), representing a mean reduction of 21.3% (SD 6.7%) of baseline body\n weight. Median weight lost was 19.6 kg, representing 20.0% of baseline body weight. Weight loss outcomes are presented\n in Table 2.\u003c\/p\u003e\n \n\u003cp\u003eTable 2. Weight Loss Outcomes\u003c\/pp\u003e\n\u003cdiv class=\"table_drawer2\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, kg (SD)\u003c\/td\u003e\n \u003ctd\u003e21.9 (6.8)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e19.6\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean weight loss, % of baseline (SD)\u003c\/td\u003e\n \u003ctd\u003e21.3% (6.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian weight loss, % of baseline\u003c\/td\u003e\n \u003ctd\u003e20.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMinimum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e15.7\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMaximum weight loss, kg\u003c\/td\u003e\n \u003ctd\u003e75.4\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cb\u003e3.3 Lean Mass Outcomes\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean lean mass loss as a percentage of total weight lost was 16.9% across all 6,990 members. The median\n lean mass loss as a percentage of total weight lost was 19.4%. A total of 890 members (12.7%) preserved or increased\n lean mass over the measurement period (lean mass delta ≥ 0). Among the 6,100 members (87.3%) who lost lean mass, the\n mean lean mass loss as a percentage of total weight lost was 22.0%. Lean mass outcomes are presented in Table 3.\u003c\/p\u003e\n \n\u003cp\u003eTable 3. Lean Mass Outcomes\u003c\/p\u003e\n\u003cdiv class=\"table_drawer3\"\u003e\n \u003ctable border=\"1\"\u003e\n \u003ctr\u003e\n \u003cth\u003eOutcome\u003c\/th\u003e\n \u003cth\u003eResult\u003c\/th\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eWeighted mean lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e16.9%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMedian lean mass loss, % of total weight lost (all members)\u003c\/td\u003e\n \u003ctd\u003e19.4%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers preserving or gaining lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e890 (12.7%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMembers losing lean mass, n (%)\u003c\/td\u003e\n \u003ctd\u003e6,100 (87.3%)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003eMean lean mass loss, % of total weight lost (among those with lean mass loss)\u003c\/td\u003e\n \u003ctd\u003e22.0%\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003ctr\u003e\n \u003ctd\u003ePublished benchmark (Prado et al., 2024; Neeland et al., 2024)\u003c\/td\u003e\n \u003ctd\u003e25–39% (range across GLP-1 trials)\u003c\/td\u003e\n \u003c\/tr\u003e\n \u003c\/table\u003e\n\u003c\/div\u003e\n \n\u003cp\u003e\u003cb\u003e3.4 Interpretation of the Weighted Mean Outcome\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe weighted mean of 16.9% reflects the aggregate population-level ratio of total lean mass change to total weight\n lost across all members. Because members who preserved or gained lean mass (12.7% of the cohort) contribute negative\n lean mass loss values to the numerator, the weighted mean is lower than the mean computed among members who lost lean\n mass exclusively (22.0%). Both measures are reported to provide transparency regarding cohort composition. The\n weighted mean is the primary outcome because it most accurately represents the population-level body composition\n impact of the program.\u003c\/p\u003e\n\u003ch4\u003e4. DISCUSSION\n\u003c\/h4\u003e\n\u003cp\u003eThis analysis demonstrates that Hume Health premium members on GLP‑1 therapy, who met defined body composition\n monitoring and AI protocol engagement criteria, experienced lean mass loss substantially below the benchmarks\n documented in published GLP‑1 clinical trials. The weighted mean lean mass loss of 16.9% of total weight lost compares\n favorably to the 25–39% range reported by Prado et al.³ and the 40–60% upper range reported in some cohorts by Neeland\n et al.²\n\u003c\/p\u003e\n\u003cp\u003eThe mechanism by which frequent body composition measurement and protocol-guided engagement may attenuate lean mass\n loss is consistent with established physiology. Skeletal muscle mass is the primary determinant of resting metabolic\n rate.⁶ Interventions that preserve lean mass during caloric restriction — including higher protein intake, resistance\n exercise, and dose calibration timed to body composition response — are documented to reduce lean mass loss during\n weight reduction. The Hume platform protocol facilitates tissue-level visibility that enables these calibrations in\n near real-time; the present analysis cannot isolate which components of the program contributed to the observed\n outcomes.\n\u003c\/p\u003e\n\u003cp\u003eThe finding that 12.7% of members preserved or gained lean mass during GLP‑1-assisted weight loss is notable. This\n subgroup is likely influenced by favorable baseline characteristics, behavioral factors, and variability in BIA\n measurement across conditions, and should not be interpreted as a program-level guarantee of lean mass preservation.\n Its inclusion in the weighted mean reduces the reported aggregate lean mass loss figure relative to analyses\n restricted to members who lost lean mass.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.1 Limitations\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis has several limitations that should be considered when interpreting results. First, the study is\n retrospective and observational, without a concurrent control group. Comparison to published clinical trial benchmarks\n involves differences in population, measurement methodology, and GLP‑1 agent. Second, body composition was measured\n via bioelectrical impedance analysis rather than dual-energy X-ray absorptiometry (DXA) or magnetic resonance imaging\n (MRI), which are considered the reference standards for lean mass quantification. BIA measurements are sensitive to\n hydration status, time of measurement, and device calibration, and may produce systematic differences relative to\n DXA-derived lean mass values. Third, the cohort consists of premium-tier members who met a minimum engagement\n threshold; results may not generalize to members with lower engagement frequency or to non-engaged GLP‑1 users.\n Fourth, no information on dietary protein intake, resistance exercise participation, or specific GLP‑1 agent and\n dosing schedule was incorporated into this analysis, and these variables are likely to influence lean mass outcomes.\n Fifth, the duration of the measurement window varied across members and was determined by the interval between peak\n and nadir weight rather than a fixed protocol period.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.2 Future Directions\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eProspective controlled study designs with standardized measurement protocols, dietary and exercise co-variate\n capture, and DXA-validated BIA calibration would provide stronger evidence for the role of high-frequency monitoring\n and AI-guided adherence in lean mass preservation during GLP‑1 therapy. Subgroup analyses examining the impact of\n engagement frequency, protein intake, resistance training participation, and GLP‑1 agent on lean mass outcomes would\n further characterize the mechanisms underlying these findings.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5. CONCLUSIONS\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAmong 6,990 Hume Health premium members on GLP‑1 therapy who met defined body composition monitoring and AI protocol\n engagement criteria, the weighted mean lean mass loss as a percentage of total weight lost was 16.9%. This is\n substantially below the 25–39% range reported in published GLP‑1 clinical trial literature. The median lean mass loss\n was 19.4%. These findings are consistent with the hypothesis that high-frequency tissue-level monitoring, combined\n with AI-guided protocol adherence and physician oversight informed by body composition data, supports favorable lean\n mass outcomes during medically assisted weight loss. Prospective controlled research is needed to confirm these\n findings and to isolate the active components of the platform protocol.\n\u003c\/p\u003e\n \n\u003ch4\u003eREFERENCES\u003c\/h4\u003e\n \n\u003cp\u003e1. Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl\n J Med. 2021;384(11):989–1002. doi:10.1056\/NEJMoa2032183.\u003c\/p\u003e\n\u003cp\u003e2. Neeland IJ, Linge J, Birkenfeld AL. Changes in lean body mass with glucagon-like peptide-1-based therapies and\n mitigation strategies. Diabetes Obes Metab. 2024;26(Suppl 4):16–27. doi:10.1111\/dom.15728.\u003c\/p\u003e\n\u003cp\u003e3. Prado CM, Phillips SM, Gonzalez MC, Heymsfield SB. Muscle matters: the effects of medically induced weight loss on\n skeletal muscle. Lancet Diabetes Endocrinol. 2024;12(11):785–787. doi:10.1016\/S2213-8587(24)00272-9.\u003c\/p\u003e\n\u003cp\u003e4. Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of\n semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553–1564. doi:10.1111\/dom.14725.\u003c\/p\u003e\n\u003cp\u003e5. Hume Health Corp. Lean Mass Preservation in GLP‑1 Members: An Internal Outcomes Analysis. 2024. Analysis of 6,990\n premium members. Methodology available on request: research@humehealth.com.\n\u003c\/p\u003e\n\u003cp\u003e6. Ravussin E, Bogardus C. Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Appl\n Physiol. 1989;66(3). PMID:2243122.\n\u003c\/p\u003e\n \n\u003cp\u003e\u003cb\u003eDisclosure Statement\n \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis analysis was conducted by Hume Health Corp using data from the Hume Health platform. Hume Health Corp is the\n developer of the body composition monitoring hardware (Hume Body Pod) and AI guidance system (Pro.f) evaluated in this\n analysis. No external funding was received. The analysis has not undergone independent peer review. Investigators have\n an inherent commercial interest in the outcomes described.\u003c\/p\u003e" }, "width": 750, "transitionDuration": 150 }

{ "type": "slideout", "contentType": "with_image", "content": { "title": "","image": "//humehealth.com/cdn/shop/files/hume_pod.webp?v=1764101038&width=932", "imageWidth": "200","imageContent": "\u003ch2\u003eAbout Hume Pod\u003c\/h2\u003e\u003cp\u003eHume Pod tracks your complete body composition with clinical-grade precision - measuring muscle mass, body fat, visceral fat, bone density, metabolic age, and 45 other metrics - then shows you exactly how your habits are changing your body over time.\u003c\/p\u003e", "secondaryContent": "\u003ch4\u003eThe only body analyzer for real progress tracking\u003c\/h4\u003e\u003cp\u003eHume Pod measures what actually determines your health and longevity, such as muscle gain, fat loss, visceral fat levels, and metabolic age.\u003c\/p\u003e\u003cp\u003eOur 8-Frequency BIA system reveals information like whether you're losing fat or just water weight, if you're building muscle even when the scale doesn't budge, dangerous visceral fat around your organs, and much more.\u003c\/p\u003e\u003ch4\u003eHow does it work?\u003c\/h4\u003e\u003cp\u003eHume Pod uses 8 electrodes and multi-frequency sensors to scan your entire body more accurately than standard scales - delivering 98% DEXA-level accuracy validated in lab studies and third-party testing. The metrics these sensors measure are:\u003c\/p\u003e\u003col\u003e\u003cli\u003eBody Fat Percentage\u003c\/li\u003e\u003cli\u003eSkeletal Muscle Mass\u003c\/li\u003e\u003cli\u003eVisceral Fat Level\u003c\/li\u003e\u003cli\u003eBone Density\u003c\/li\u003e\u003cli\u003eMetabolic Age\u003c\/li\u003e\u003cli\u003eBody Water Percentage\u003c\/li\u003e\u003cli\u003eProtein Mass\u003c\/li\u003e\u003cli\u003eBMI \u0026 Body Mass Index\u003c\/li\u003e\u003cli\u003eSegmental Analysis (arms, legs, torso measured separately)\u003c\/li\u003e\u003c\/ol\u003e\u003cp\u003eAdvanced algorithms analyze these measurements to detect patterns you can't see: muscle building in specific body parts, fat loss masked by water retention, declining metabolic health, visceral fat accumulation, and more.\u003c\/p\u003e" }, "width": 750, "transitionDuration": 700 }

48,252+ Reviews

The Hume Band

$0

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Turn Back the Clock, One Habit at a Time

Discover which daily habits speed up or slow down aging, so you can make smarter health choices, extend your healthspan, and enjoy more of life’s best moments.

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2,955 Reviews

HSA/FSA eligible

MEDICAL-GRADE INSIGHTS

Track biology, not just activity.

Hume band isn’t just another wearable

Eating clean and training hard, but aging faster? Hume Band catches overtraining, poor recovery, and hidden stress that age you faster than your habits should allow.

How it Works

metabolic capacity

Recovery & Cellular Repair

Optimize your body’s ability to heal, recharge, and fight aging at the cellular level.

Chronic illness detection

May indicate the
onset of an illness

Identify potential health issues early and take action before they become serious.

Metabolic Momentum

Adding Years To Your
Life

Focus on building and reframing habits that will add years to your life, keep you stronger, sharper, and healthier for decades to come

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Members gained an average of +6.8 Years of extra lifespan from healthier habits

Metabolic capacity

Wake Up Stronger, Healthier & More Resilient 

Measure your Metabolic Capacity—a key indicator of how efficiently your body performs and recovers. The higher it is, the better your endurance, the faster your recovery, and the stronger your resilience as you age.

Electrocardiogram

Metabolic momentum

Stay Active, Energized & Aging-Resistant

Get real-time insights into whether your daily choices are slowing aging or speeding it up. Metabolic Momentum shows you exactly where you're headed—so you can take control, adjust fast, and build a longer, stronger life.

Digital stethoscope

Chronic Illness Detection

Catch Health Risks Before They Slow You Down

By analyzing your body’s signals, Hume Band may detect early signs of illness—helping you take action before small issues become big problems

Oxymeter

Digital stethoscope

Metabolic capacity

Wake Up Stronger, Healthier & More Resilient 

Measure your Metabolic Capacity—a key indicator of how efficiently your body performs and recovers. The higher it is, the better your endurance, the faster your recovery, and the stronger your resilience as you age.

Metabolic momentum

Stay Active, Energized & Aging-Resistant

Get real-time insights into whether your daily choices are slowing aging or speeding it up. Metabolic Momentum shows you exactly where you're headed—so you can take control, adjust fast, and build a longer, stronger life.

Chronic Illness Detection

Catch Health Risks Before They Slow You Down

By analyzing your body’s signals, Hume Band may detect early signs of illness—helping you take action before small issues become big problems

Tim Bio-Hacker

Europe’s Leading Biohacker

Sarah Bacon

Olympian - Silver Medalist l 3x World Silver Medalist l 5x NCAA Champion

Belal Muhammad

2x UFC World Champion

"I optimize everything—sleep, nutrition, cold exposure—and nothing closes the loop like Hume. Watching my Metabolic Momentum rise and biological age drop is addictive."

Hume User

Brianna McNeal

Olympic Runner

“I’ve trained with every wearable, but Hume truly connects the dots. In 30 days my recovery improved, reaction time sharpened, and my biological age dropped by 1.8 years”

Hume User

Emily Loogman

T&F All-American l 3x CF Games l Hybrid Athlete

“I’ve trained with every wearable, but Hume truly connects the dots. In 30 days my recovery improved, reaction time sharpened, and my biological age dropped by 1.8 years”

Hume User

Brianna McNeal

Olympic Runner

Frank gore

5× Pro Bowl NFL Legend

NFL

The Hume Band isn’t another tracker

Hume shows you what’s happening inside your body — not just how hard you worked.

Comparison

Hume Band

Others

Focus

Longevity, disease detection,
healthspan

Strain, recovery, athletic
performance, lifespan limited to
premium*

Data Ownership

You own your health
data (exportable)

You don’t own your
data (locked behind membership)

Subscription
Required?

No, One time purchase
with option to upgrade to premium

Yes - $30/month (or more)

Body Composition
Tracking

Yes, via Hume Pod

No

Digital Twin / AI
insights

Yes, Future-ready
predictive insights

No (basic insights only)

Holistic Health
Coaching

Yes, Science-backed, longevity-
focused

Limited to performance/recovery tips

Longevity Metrics
(HRV, Resilience)

Yes, with longevity index,
metabolic momentum
and capacity

HRV only

Price

One-time $199-249 (no
subscription)

$300-480/year (ongoing)

Your True Age

Coaching That Targets Aging — Not Just Strain

Other trackers focus on workouts and recovery.

Hume is a full longevity system — with tools for disease detection, aging, and health optimization.

Biological Age is a label.

Metabolic Capacity is a system.

Hume says:

Hume says:
“Your momentum is 82. You gained 3.2 days of life last week — here’s how to gain more.”

Others say:

Others say:
“You’re biologically 37.”

We don’t just tell you how old you are.
We help you get younger — and prove it

Lifetime Access

No Monthly Fees to Access Your Own Health

Hume:

Hume: One-time purchase. Premium
optional*

Others:

Others: $30/month just to see
your data.

We believe your health data shouldn’t be locked behind a subscription.
With Hume Band, you own the device — and your insights. Forever.

Longevity

Real Longevity Metrics — Not Just HRV

Hume:

Hume: Metabolic Momentum, Capacity,
Resilience, and a full Longevity Index.

Others:

Others: Just lifespan. HRV is one
piece of the puzzle.

Hume gives you the whole picture — and shows how your body is actually changing over time.

Know Your Body

Direct Measurement — Not Just Inference

Others guess aging from HRV, sleep, and heart rate.

Hume measures it — directly.

The Hume Band + Hume Pod goes track real bio-markers in fat, muscle, and tissue — where aging actually
happens.

Inference is helpful.

But direct data is powerful.

Helping your body evolve
with every phase of life

Whether you're #1 in the world or on day 1 of your journey, The Hume Pod helps you optimize your health, fitness, and life.

Lifespan

Chronic Illness

Sleep

Heart health

Daily energy

Activity & movement

Biological age

Discover how old your body really is.
Hume updates your Biological Age in real time based on sleep, recovery, and stress—so you can literally watch yourself grow younger.

Pace of aging

See how quickly your body is aging compared to your chronological age.
Hume turns complex data into one clear trend: are you aging faster or slower than you should?

Days added

Every action adds up.
Hume shows how many extra days of life you’ve earned through better sleep, recovery, and stress management

Metabolic momentum

Your daily habits either speed up or slow down aging.
Hume tracks your Metabolic Momentum—how your recovery, energy, and stress are compounding toward a longer life.

Senior woman holding a coffee cup with a clear blue sky background

Health score

Your heart reveals how well your body bounces back.
This index measures how efficiently your heart recovers after strain—showing whether your rest and recovery are truly restoring your system or leaving you running on empty.

Chronic illness detection

When your daily rhythm and heart rhythm fall out of sync, your body pays the price.
Hume tracks your circadian HRV patterns to detect misalignment caused by stress, poor sleep, or irregular habits—so you can realign your internal clock and restore balance.

Coaching

Not all effort creates growth.
This ratio reveals whether your workouts and daily exertion are helping you build resilience—or tipping into overtraining and fatigue.
Find your personal sweet spot between pushing harder and living longer.

Sleep score

Finally, an honest answer to “How well did I really sleep?”
 Your Sleep Score reflects your total rest, heart rate variability (HRV), night time movement, and sleep regularity—revealing how restorative your sleep truly was and how it impacts your biological age.

Sleep stages

Go beyond hours of rest with a clear breakdown of your deep, REM, and light sleep patterns.

See exactly where your recovery is happening—and where it’s falling short—so you can optimize both rest and resilience.

Sleep debt

Most wearables stop at last night. Hume tracks the sleep debt your body accumulates over time—the gap between what you need and what you actually get.

Repay your sleep debt, rebuild recovery, and slow your pace of aging night by night.

Blood oxygen sensing

Hume continuously monitors your blood oxygen saturation (SpO₂) to detect potential breathing disturbances or sleep-related issues before they impact your health. Your nightly data becomes a powerful early-warning signal for better long-term vitality.

Bedtime guidance

Smart reminders powered by your circadian rhythm help you wind down before fatigue sets in. Hume learns your body’s natural patterns and recommends when to disconnect—so you fall asleep faster and wake sharper.

Recovery efficiency index

Your heart reveals how well your body bounces back.
This index measures how efficiently your heart recovers after strain—showing whether your rest and recovery are truly restoring your system or leaving you running on empty.

Circadian hrv desynchronization

When your daily rhythm and heart rhythm fall out of sync, your body pays the price.
Hume tracks your circadian HRV patterns to detect misalignment caused by stress, poor sleep, or irregular habits—so you can realign your internal clock and restore balance.

Strain-to-benefit ratio

Not all effort creates growth.
This ratio reveals whether your workouts and daily exertion are helping you build resilience—or tipping into overtraining and fatigue.
Find your personal sweet spot between pushing harder and living longer.

Sleep–cardiovascular correlation

Your heart doesn’t just beat while you sleep—it heals.
Hume analyzes how your sleep quality directly affects cardiovascular recovery, showing how deep rest strengthens your heart and slows aging over time.

Metabolic capacity

Your body runs on energy—and Hume shows you how to protect it, rebuild it, and make it last longer.
Your Metabolic Capacity reveals how much energy you have to perform, train, and recover—then helps you recharge faster.

Recovery

Know exactly when to push and when to pause.
Hume tracks your heart resilience, sleep debt, and stress response to show how well your body is rebounding from strain.

Stress

Not all stress is bad—only unmanaged stress accelerates aging.
Hume monitors your physiological stress in real time and guides you to balance pressure with recovery.

Daily guidance

Your body gives signals—Hume translates them into action.
Get personalized recommendations on when to rest, move, or recharge, so your energy lasts longer and your body ages slower.

Activity score

Track your daily movement, consistency, and recovery to find your ideal balance between effort and rest.
Hume shows whether your activity is fueling longevity—or quietly draining it.

Longevity load

Every workout adds to your Longevity Load—a measure of how your training contributes to your lifespan.
Train smarter, not harder, by maximizing the health benefits of movement while minimizing wear and tear.

Personalized activity goals

Your optimal goal changes every day. 
Hume adapts your activity targets based on recovery, sleep debt, and metabolic capacity—so every step supports your long-term health.

Every Choice shape your future

Hume Band Helps You Make the Right Ones.

Powered by AI and Machine Learning, Hume+ is an enhanced in-app health
experience to help anyone create routines that provide a positive feedback loop.

Make smarter health choices

Understand how daily habit impacts your longevity and receive data driven health guidance on adopting a holistic health approach

Increase body energy levels

Track and get guidance on how to better maintain endurance, faster recovery, and greater resilience with age—like sharpening a sword that lasts longer, not dulling with time.

Get ahead of illness

We constantly scan your biometrics to detect early signs of stress, immune decline, inflammation, and recovery delays—so you can act before illness takes hold.

Make the time wait for you

No more guessing. Get daily and weekly personalized insights, backed by cutting-edge science, to optimize your health, slow aging, and extend your lifespan.

Join a Supportive Community
of Over 1.2 Million Users

🎉 SPRING Sale: Use Code SPRING40 to get 40% OFF

Free App + Free shipping Included ✈️

2,955 Reviews

Hume Band

18 interest-free payments of $15

~~$356~~ $267

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Make your money go further

We handle eligibility. Guaranteed.

Receipts, handled

Forget filing for reimbursements. We got you.

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Use your credit card. We'll help with the rest.

Frequently Asked Questions

What makes the Hume Band different from other wearables?

The Hume Band isn’t just about fitness—it’s about future-proofing your health. We track longevity markers, showing how your habits are either speeding up or slowing down aging. Our unique metrics, like Metabolic Momentum and Metabolic Capacity, help you live longer, prevent chronic illness, and optimize your body for a healthier future. This isn’t just data—it’s a roadmap to a longer, stronger life.

What raw data does the Hume Band track and measure?

Continuous heart rate monitoring
Heart Rate Variability (HRV)
Blood oxygen levels (SpO2)
Sleep stages (light, deep, REM, awake)
Sleep quality and efficiency
Activity levels and movement patterns
Strain and recovery
Skin temperature
Blood Pressure (To be released in future app update, pending FDA approval)

What is “longevity,” and how does the Hume Band support it?

Longevity means living a longer, healthier life—free from preventable diseases. The Hume Band helps by continuously tracking and interpreting signals from your body to:

Spot early signs of imbalance or chronic risk
Monitor how daily habits impact your aging process
Provide insights to improve healthspan—not just lifespan

On average Hume Band user gained an extra 39 days of extra life in their first year with Hume

Our tools are designed to help you make small changes that compound into big results over time.

Do I need a subscription to use the Band?

No subscription is required to use the Band or access your raw data.

However, if you'd like AI-driven insights, personalized longevity coaching, and deep health analysis, you can subscribe to Hume Premium starting at $8.99/month. This supports the computing power needed to deliver real-time, intelligent health feedback.

Is the Band waterproof or sweatproof?

Yes. The Hume Band is IP68-rated—meaning it's:

Dustproof
Water-resistant up to 1 meter (3.2 feet) for up to 2 hours

Perfect for showers, swimming, and workouts—no interruptions.

What is the battery life of the Hume Band?

Up to 4-5 days of battery life with typical use
Fast charging: Full charge in approximately 30 minutes

Note: Frequent syncing and continuous tracking may slightly reduce battery life.

Is the Band compatible with my phone?

Yes. The Hume Band works with:

iOS Devices

iPhone 8 and newer
iOS 14.0 and above

Android Devices

Android 8.0 (Oreo) and above

Can I buy the Band without the Hume Pod?

Yes. The Hume Band works perfectly on its own for daily tracking.

The Hume Pod is an optional companion device that scans your body composition (body fat, muscle mass, etc.) for a more complete health picture—but it's not required.

What’s your return or exchange policy?

We offer a 45-day, no-questions-asked return or exchange policy. Try it risk-free.

Is my health data secure?

Yes. Your health data is:

Encrypted end-to-end
Stored on HIPAA-compliant servers
Only accessible to you (or your authorized providers if you choose)

We prioritize your privacy and never sell your data. You’re in control at every step.

The Hume Band

MEDICAL-GRADE INSIGHTS

Track biology, not just activity.

Measure your Metabolic Capacity—a key indicator of how efficiently your body performs and recovers. The higher it is, the better your endurance, the faster your recovery, and the stronger your resilience as you age.

Get real-time insights into whether your daily choices are slowing aging or speeding it up. Metabolic Momentum shows you exactly where you're headed—so you can take control, adjust fast, and build a longer, stronger life.

By analyzing your body’s signals, Hume Band may detect early signs of illness—helping you take action before small issues become big problems

Measure your Metabolic Capacity—a key indicator of how efficiently your body performs and recovers. The higher it is, the better your endurance, the faster your recovery, and the stronger your resilience as you age.

Get real-time insights into whether your daily choices are slowing aging or speeding it up. Metabolic Momentum shows you exactly where you're headed—so you can take control, adjust fast, and build a longer, stronger life.

By analyzing your body’s signals, Hume Band may detect early signs of illness—helping you take action before small issues become big problems

Hume Band Helps You Make the Right Ones.

The Hume Band

Your body's early warning system

50% Off The Hume Body Pod

Not satisfied within 45 days? Get a full refund

“If you’re serious about staying healthy for the long run, this is the one tool I keep coming back too.”

Looking for more information?

About the app

What makes the Hume Band different?

Tech specification

FAQs

1. What raw data does the Hume Band track and measure?

2. What is “longevity,” and how does the Hume Band support it?

3. Do I need a subscription to use the Band?

4. Is the Band waterproof or sweatproof?

5. What is the battery life of the Hume Band?

6. What wrist sizes does the Band fit?

7. Is the Band compatible with my phone?

Can I buy the Band without the Hume Pod?

Shipping & returns

🏆 The Award-Winning Longevity Band

Frequently Asked Questions

What makes the Hume Band different from other wearables?

What raw data does the Hume Band track and measure?

What is “longevity,” and how does the Hume Band support it?

Do I need a subscription to use the Band?

Is the Band waterproof or sweatproof?

What is the battery life of the Hume Band?

Is the Band compatible with my phone?

Can I buy the Band without the Hume Pod?

What’s your return or exchange policy?

Is my health data secure?

Hume Band Helps You
Make the Right Ones.